a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect.
Details
Serval ID
serval:BIB_815663C192BD
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
a-tDCS on the ipsilesional parietal cortex boosts the effects of prism adaptation treatment in neglect.
Journal
Restorative neurology and neuroscience
ISSN
1878-3627 (Electronic)
ISSN-L
0922-6028
Publication state
Published
Issued date
2015
Peer-reviewed
Oui
Volume
33
Number
5
Pages
647-662
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
The aim of the study is to compare the effects of multiple sessions of cathodal (c-tDCS) or anodal tDCS (a-tDCS) in modulating the beneficial effects of prism adaptation (PA) treatment in neglect patients.
30 neglect patients were submitted to 10 daily sessions of PA treatment. Patients were pseudo-randomly divided into 3 groups. In the c-tDCS-group, each PA session was coupled with 20 minutes of cathodal stimulation of the left, intact PPC; in the a-tDCS-group, anodal stimulation was applied to PPC of the damaged hemisphere; in the Sham group, sham stimulation was applied. Neglect was evaluated before and after treatment with the Behavioral Inattention Test.
Combined tDCS-PA treatment induced stronger neglect improvement in the a-tDCSgroup as compared to the Sham group. No improvement was found in the c-tDCS group, with respect to that normally induced by PA and found in the Sham group.
c-tDCS abolished neglect amelioration after PA, possibly because stimulation affected the sensorimotor network controlling prism adaptation. Instead, a-tDCS PPC boosted neglect amelioration after PA probably thanks to increased excitability of residual tissue in the lesioned hemisphere, which in turn might reduce dysfunctional over-excitability of the intact hemisphere.
30 neglect patients were submitted to 10 daily sessions of PA treatment. Patients were pseudo-randomly divided into 3 groups. In the c-tDCS-group, each PA session was coupled with 20 minutes of cathodal stimulation of the left, intact PPC; in the a-tDCS-group, anodal stimulation was applied to PPC of the damaged hemisphere; in the Sham group, sham stimulation was applied. Neglect was evaluated before and after treatment with the Behavioral Inattention Test.
Combined tDCS-PA treatment induced stronger neglect improvement in the a-tDCSgroup as compared to the Sham group. No improvement was found in the c-tDCS group, with respect to that normally induced by PA and found in the Sham group.
c-tDCS abolished neglect amelioration after PA, possibly because stimulation affected the sensorimotor network controlling prism adaptation. Instead, a-tDCS PPC boosted neglect amelioration after PA probably thanks to increased excitability of residual tissue in the lesioned hemisphere, which in turn might reduce dysfunctional over-excitability of the intact hemisphere.
Keywords
Adaptation, Physiological/physiology, Adaptation, Psychological/physiology, Aged, Aged, 80 and over, Double-Blind Method, Female, Functional Laterality, Humans, Lenses, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Parietal Lobe/pathology, Parietal Lobe/physiopathology, Perceptual Disorders/pathology, Perceptual Disorders/physiopathology, Perceptual Disorders/therapy, Random Allocation, Stroke/pathology, Stroke/physiopathology, Stroke/therapy, Transcranial Direct Current Stimulation/adverse effects, Transcranial Direct Current Stimulation/methods, Treatment Outcome, Neglect, Prism Adaptation, tDCS
Pubmed
Web of science
Create date
25/03/2025 19:58
Last modification date
27/03/2025 9:09
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