Comment modéliser les événements de la fibrose cutanée? [How to model the events in cutaneous fibrosis?]

Details

Serval ID
serval:BIB_814A74A710BC
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Comment modéliser les événements de la fibrose cutanée? [How to model the events in cutaneous fibrosis?]
Journal
Medecine sciences
Author(s)
Vozenin-Brotons M.C., Mauviel A.
ISSN
0767-0974 (Print)
ISSN-L
0767-0974
Publication state
Published
Issued date
02/2006
Peer-reviewed
Oui
Volume
22
Number
2
Pages
172-177
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Abstract
Skin fibrosis is classically seen as the consequence of chronic inflammation and altered healing response that is characterized by the differentiation of fibroblasts into secretory myofibroblasts and accumulation of connective tissue. Although fibrosis severely affects organ function and causes esthetic defects, no effective therapy is currently available to attenuate the fibrogenic process probably because the fibrogenic process is more complex than previously thought. Indeed, it might involve several interacting and mutually dependent cell types (fibroblasts, keratinocytes, endothelial cells, inflammatory cells), numerous paracrine factors, bio-active molecules and micro-environmental stimuli (growth factors, vasoactive peptides, balance between pro- and anti-inflammatory cytokines, coagulation system, reactive oxygen species, extracellular matrix...). In this perspective, the traditional approach that model individual cell response in simple cell culture system is probably inadequate and too simplistic. This article reviews the new models used to study skin fibrosis in vitro, in organotypic culture systems and in vivo and examines how these different models might be used to identify new molecular pathways involved in fibrogenesis. The monolayer cultures allow the study of fibrogenic signals induced by a single factor on a single cell type. Isolation of cells from fibrotic tissue allows to define the fibrogenic differentiation acquired in vivo. The organotypic models allow cell to cell and cell to matrix interaction and the experimental models in pigs and mice allowed studies in integrated physiological systems. These various and complementary models would also provide new tools to develop and test new drugs and treatments.

Keywords
Animals, Bleomycin/toxicity, Cell Differentiation, Dermatitis/pathology, Disease Models, Animal, Drug Eruptions/pathology, Fibroblasts/pathology, Fibrosis, Genetic Predisposition to Disease, Humans, Hyperplasia, Mice, Mice, Inbred C57BL, Mice, Mutant Strains, Models, Biological, Muscle Cells/pathology, Radiodermatitis/pathology, Signal Transduction, Skin/drug effects, Skin/pathology, Sus scrofa
Pubmed
Web of science
Open Access
Yes
Create date
30/04/2018 14:36
Last modification date
20/08/2019 14:41
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