Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.

Details

Serval ID
serval:BIB_81177BECC2D0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Dietary sodium intake does not alter renal potassium handling and blood pressure in healthy young males.
Journal
Nephrology, dialysis, transplantation
Author(s)
Pechère-Bertschi A., Olivier V., Burnier M., Udwan K., de Seigneux S., Ponte B., Maillard M., Martin P.Y., Feraille E.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Publication state
Published
Issued date
25/02/2022
Peer-reviewed
Oui
Volume
37
Number
3
Pages
548-557
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
The effects of sodium (Na+) intakes on renal handling of potassium (K+) are insufficiently studied.
We assessed the effect of Na+ on renal K+ handling in 16 healthy males assigned to three 7-day periods on low salt diet [LSD, 3 g sodium chloride (NaCl)/day], normal salt diet (NSD, 6 g NaCl/day) and high salt diet (HSD, 15 g NaCl/day), with constant K+ intake. Contributions of distal NaCl co-transporter and epithelial Na+ channel in the collecting system on K+ and Na+ handling were assessed at steady state by acute response to 100 mg oral hydrochlorothiazide and with addition of 10 mg of amiloride to hydrochlorothiazide, respectively.
Diurnal blood pressure slightly increased from 119.30 ± 7.95 mmHg under LSD to 123.00 ± 7.50 mmHg (P = 0.02) under HSD, while estimated glomerular filtration rate increased from 133.20 ± 34.68 mL/min under LSD to 187.00 ± 49.10 under HSD (P = 0.005). The 24-h K+ excretion remained stable on all Na+ intakes (66.28 ± 19.12 mmol/24 h under LSD; 55.91 ± 21.17 mmol/24 h under NSD; and 66.81 ± 20.72 under HSD, P = 0.9). The hydrochlorothiazide-induced natriuresis was the highest under HSD (30.22 ± 12.53 mmol/h) and the lowest under LSD (15.38 ± 8.94 mmol/h, P = 0.02). Hydrochlorothiazide increased kaliuresis and amiloride decreased kaliuresis similarly on all three diets.
Neither spontaneous nor diuretic-induced K+ excretion was influenced by Na+ intake in healthy male subjects. However, the respective contribution of the distal convoluted tubule and the collecting duct to renal Na+ handling was dependent on dietary Na+ intake.
Keywords
Blood Pressure, Humans, Kidney Tubules, Distal, Male, Natriuresis, Potassium, Potassium, Dietary/pharmacology, Sodium, Sodium Chloride, Dietary, Sodium, Dietary/pharmacology, hypertension, potassium, renal tubule, renin–angiotensin–aldosterone system, sodium intake
Pubmed
Web of science
Open Access
Yes
Create date
18/02/2021 18:25
Last modification date
29/03/2022 6:36
Usage data