Effective purifying selection in ancient asexual oribatid mites.

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License: CC BY 4.0
Serval ID
serval:BIB_80B51A083728
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Effective purifying selection in ancient asexual oribatid mites.
Journal
Nature communications
Author(s)
Brandt A., Schaefer I., Glanz J., Schwander T., Maraun M., Scheu S., Bast J.
ISSN
2041-1723 (Electronic)
ISSN-L
2041-1723
Publication state
Published
Issued date
12/10/2017
Peer-reviewed
Oui
Volume
8
Number
1
Pages
873
Language
english
Abstract
Sex is beneficial in the long term because it can prevent mutational meltdown through increased effectiveness of selection. This idea is supported by empirical evidence of deleterious mutation accumulation in species with a recent transition to asexuality. Here, we study the effectiveness of purifying selection in oribatid mites which have lost sex millions of years ago and diversified into different families and species while reproducing asexually. We compare the accumulation of deleterious nonsynonymous and synonymous mutations between three asexual and three sexual lineages using transcriptome data. Contrasting studies of young asexual lineages, we find evidence for strong purifying selection that is more effective in asexual as compared to sexual oribatid mite lineages. Our results suggest that large populations likely sustain effective purifying selection and facilitate the escape of mutational meltdown in the absence of sex. Thus, sex per se is not a prerequisite for the long-term persistence of animal lineages.Asexual reproduction is thought to be an evolutionary dead end in eukaryotes because deleterious mutations will not be purged effectively. Here, Brandt and colleagues show that anciently asexual oribatid mites in fact have reduced accumulation of deleterious mutations compared to their sexual relatives.
Keywords
Animals, DNA, Mitochondrial/chemistry, Mites/genetics, Mites/physiology, Mutation, Mutation Rate, Phylogeny, Population Density, Reproduction, Reproduction, Asexual, Selection, Genetic, Transcriptome
Pubmed
Web of science
Open Access
Yes
Create date
16/10/2017 16:15
Last modification date
22/09/2021 5:38
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