Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.

Details

Serval ID
serval:BIB_80A455CDE58A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Constitutively active G protein-coupled receptors: potential mechanisms of receptor activation.
Journal
Journal of Receptor and Signal Transduction Research
Author(s)
Scheer A., Cotecchia S.
ISSN
1079-9893 (Print)
ISSN-L
1079-9893
Publication state
Published
Issued date
1997
Volume
17
Number
1-3
Pages
57-73
Language
english
Abstract
Mutations of G protein-coupled receptors can increase their constitutive (agonist-independent) activity. Some of these mutations have been artificially introduced by site-directed mutagenesis, others occur spontaneously in human diseases. The analysis of the constitutively active G protein-coupled receptors has provided important informations about the molecular mechanisms underlying receptor activation and drug action.
Keywords
GTP-Binding Proteins, Humans, Isomerism, Models, Molecular, Mutagenesis, Site-Directed, Receptors, Cell Surface/genetics, Receptors, Cell Surface/metabolism
Pubmed
Web of science
Create date
24/01/2008 12:05
Last modification date
20/08/2019 15:41
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