Virus d'Epstein-Barr et maladie de Hodgkin: l'exemple du centre Tunisien [Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia]
Details
Serval ID
serval:BIB_807543DF0C16
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Virus d'Epstein-Barr et maladie de Hodgkin: l'exemple du centre Tunisien [Epstein-Barr virus in Hodgkin's disease: the example of central Tunisia]
Journal
Annales de pathologie
ISSN
0242-6498 (Print)
ISSN-L
0242-6498
Publication state
Published
Issued date
04/2002
Peer-reviewed
Oui
Volume
22
Number
2
Pages
96-101
Language
french
Notes
Publication types: English Abstract ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The purpose of this study was to evaluate the prevalence of Epstein-Barr virus in Hodgkin disease in Tunisia through a series of 77 cases. Association with Epstein-Barr virus was demonstrated by Epstein-Barr encoded early RNA transcripts (EBER) in situ hybridization in 70% of cases and by latent membrane protein 1 (LMP1) immunohistochemistry in 58.4% of cases. EBER positive cases were more frequent in extreme age classes (<15 and>54 years) there was no correlation with sex, histologic sub-type and clinical stage. Our findings show a high prevalence for EBV infection in Tunisian Hodgkin's disease particularly among extreme ages.
Keywords
Adolescent, Adult, Aged, Child, Child, Preschool, Epstein-Barr Virus Infections/complications, Epstein-Barr Virus Infections/epidemiology, Female, Herpesvirus 4, Human/isolation & purification, Hodgkin Disease/complications, Hodgkin Disease/virology, Humans, In Situ Hybridization, Male, Middle Aged, Prevalence, Tunisia/epidemiology, Viral Matrix Proteins/analysis
Pubmed
Web of science
Create date
17/10/2023 10:10
Last modification date
20/10/2023 6:10
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