Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors

Details

Serval ID
serval:BIB_8037F6DE8496
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Acceleration of pubertal development following central blockade of the Y1 subtype of neuropeptide Y receptors
Journal
Regulatory Peptides
Author(s)
Pralong  F. P., Voirol  M., Giacomini  M., Gaillard  R. C., Grouzmann  E.
ISSN
0167-0115 (Print)
Publication state
Published
Issued date
11/2000
Volume
95
Number
1-3
Pages
47-52
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov 24
Abstract
Pubertal development results from the coordinate secretion of gonadotropin-releasing hormone (GnRH) by hypothalamic GnRH neurons. Central administration of neuropeptide Y (NPY) to prepubertal rats can indefinitely delay sexual maturation by inhibiting this GnRH secretion. The aim of the present study was to further investigate the physiological role of NPY in pubertal development, and to assess the potential involvement of its Y1 receptor subtype in this setting. The timing of pubertal development was determined in juvenile female rats receiving chronic i.c.v. infusion of a specific Y1 receptor antagonist (BIBP 3226), and compared with controls. Although treatment with BIBP 3226 did not affect the age at vaginal opening, animals receiving the Y1 antagonist experienced a quicker progression through puberty, corroborated by a significant increase in pituitary luteinizing hormone content. This effect of BIBP3226 on the gonadotrope axis occurred without apparent toxicity, but was accompanied by a transient decrease in body weight gain on the first day of treatment, suggesting an effect on appetite. Together, our results add to the evidence in favour of a role for NPY in the onset of puberty. They are entirely consistent with the proposed inhibition exerted by endogenous hypothalamic NPY before the onset of pubertal development. They also suggest that the Y1 subtype of NPY receptors is involved in this effect.
Keywords
Aging Animals Arginine/*analogs & derivatives/pharmacology Body Weight/drug effects Female Hypothalamus/growth & development/metabolism Luteinizing Hormone/blood/metabolism Neuropeptide Y/metabolism Pituitary Gland/growth & development/metabolism Rats Rats, Wistar Receptors, Neuropeptide Y/*antagonists & inhibitors/physiology Sexual Maturation/drug effects/*physiology Vagina/drug effects/growth & development Weight Gain/drug effects
Pubmed
Web of science
Create date
25/01/2008 17:26
Last modification date
20/08/2019 15:40
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