Analyzing Femorotibial Cartilage Thickness Using Anatomically Standardized Maps: Reproducibility and Reference Data.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_80203A1DA9FB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Analyzing Femorotibial Cartilage Thickness Using Anatomically Standardized Maps: Reproducibility and Reference Data.
Journal
Journal of clinical medicine
Author(s)
Favre J., Babel H., Cavinato A., Blazek K., Jolles B.M., Andriacchi T.P.
ISSN
2077-0383 (Print)
ISSN-L
2077-0383
Publication state
Published
Issued date
26/01/2021
Peer-reviewed
Oui
Volume
10
Number
3
Pages
461
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Alterations in cartilage thickness (CTh) are a hallmark of knee osteoarthritis, which remain difficult to characterize at high resolution, even with modern magnetic resonance imaging (MRI), due to a paucity of standardization tools. This study aimed to assess a computational anatomy method producing standardized two-dimensional femorotibial CTh maps. The method was assessed with twenty knees, processed following three common experimental scenarios. Cartilage thickness maps were obtained for the femorotibial cartilages by reconstructing bone and cartilage mesh models in tree-dimension, calculating three-dimensional CTh maps, and anatomically standardizing the maps. The intra-operator accuracy (median (interquartile range, IQR) of -0.006 (0.045) mm), precision (0.152 (0.070) mm), entropy (7.02 (0.71) and agreement (0.975 (0.020))) results suggested that the method is adequate to capture the spatial variations in CTh and compare knees at varying osteoarthritis stages. The lower inter-operator precision (0.496 (0.132) mm) and agreement (0.808 (0.108)) indicate a possible loss of sensitivity to detect differences in a setting with multiple operators. The results confirmed the promising potential of anatomically standardized maps, with the lower inter-operator reproducibility stressing the need to coordinate operators. This study also provided essential reference data and indications for future research using CTh maps.
Keywords
cartilage, knee, morphology, osteoarthritis, pattern, registration
Pubmed
Web of science
Open Access
Yes
Create date
08/02/2021 14:14
Last modification date
30/04/2021 7:12
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