Brain derived neurotrophic factor circulating levels in patients undergoing IVF.
Details
Serval ID
serval:BIB_7FCCE7AC35B8
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Brain derived neurotrophic factor circulating levels in patients undergoing IVF.
Journal
Journal of assisted reproduction and genetics
ISSN
1058-0468 (Print)
ISSN-L
1058-0468
Publication state
Published
Issued date
10/2007
Peer-reviewed
Oui
Volume
24
Number
10
Pages
477-480
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
The aim of the study was to measure circulating BDNF levels, a neurotrophin recently identified in the ovary, in parallel with estradiol, to verify if assessing this factor could add any predictive value to the outcome of in vitro fertilization.
Blood sampling for BDNF and estradiol was performed in 23 subjects undergoing IVF on day 1 (D1), day 8 (D8), day of HCG administration (DHCG) and day of oocyte retrieval.(DOR).
There was a positive correlation between BDNF and estradiol throughout the stimulation cycle in all subjects. In both pregnant and nonpregnant patients, the values of BDNF grew significantly only between D8 and DHCG and remained constant until DOR. Between-group comparisons showed no statistically significant differences in both BDNF and estradiol values throughout the IVF cycle.
Although BDNF plasma concentrations are not seemingly predictive of IVF outcome, this neurotrophin is highly correlated to estradiol levels and seems to be an important factor especially in the periovulatory period.
Blood sampling for BDNF and estradiol was performed in 23 subjects undergoing IVF on day 1 (D1), day 8 (D8), day of HCG administration (DHCG) and day of oocyte retrieval.(DOR).
There was a positive correlation between BDNF and estradiol throughout the stimulation cycle in all subjects. In both pregnant and nonpregnant patients, the values of BDNF grew significantly only between D8 and DHCG and remained constant until DOR. Between-group comparisons showed no statistically significant differences in both BDNF and estradiol values throughout the IVF cycle.
Although BDNF plasma concentrations are not seemingly predictive of IVF outcome, this neurotrophin is highly correlated to estradiol levels and seems to be an important factor especially in the periovulatory period.
Keywords
Adult, Brain-Derived Neurotrophic Factor/blood, Estradiol/blood, Female, Fertilization in Vitro, Humans, Pregnancy, Pregnancy Outcome
Pubmed
Web of science
Create date
15/09/2023 12:25
Last modification date
27/09/2023 6:44