Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Details
Serval ID
serval:BIB_7F88EFC0BECB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Journal
Journal of immunology
ISSN
1550-6606 (Electronic)
ISSN-L
0022-1767
Publication state
Published
Issued date
15/07/2009
Peer-reviewed
Oui
Volume
183
Number
2
Pages
797-801
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Abstract
IL-27 has recently been identified as a differentiation factor for the generation of IL-10-producing regulatory type 1 (Tr1) T cells. However, how IL-27 induces the expansion of Tr1 cells has not been elucidated. In this study we demonstrate that IL-27 drives the expansion and differentiation of IL-10-producing murine Tr1 cells by inducing three key elements: the transcription factor c-Maf, the cytokine IL-21, and the costimulatory receptor ICOS. IL-27-driven c-Maf expression transactivates IL-21 production, which acts as an autocrine growth factor for the expansion and/or maintenance of IL-27-induced Tr1 cells. ICOS further promotes IL-27-driven Tr1 cells. Each of those elements is essential, because loss of c-Maf, IL-21-signaling, or ICOS decreases the frequency of IL-27-induced differentiation of IL-10-producing Tr1 cells.
Keywords
Animals, Antigens, Differentiation, T-Lymphocyte/genetics, Antigens, Differentiation, T-Lymphocyte/physiology, Cell Differentiation, Inducible T-Cell Co-Stimulator Protein, Interleukin-10/biosynthesis, Interleukins/genetics, Interleukins/immunology, Interleukins/physiology, Mice, Proto-Oncogene Proteins c-maf/genetics, Proto-Oncogene Proteins c-maf/physiology, T-Lymphocytes, Regulatory/cytology, T-Lymphocytes, Regulatory/metabolism, Transcriptional Activation
Pubmed
Web of science
Open Access
Yes
Create date
21/08/2018 16:12
Last modification date
20/08/2019 14:40