Stimulation of the dorsolateral prefrontal cortex modulates brain cue reactivity to reward (un)availability
Details
![Ressource 1](https://serval.unil.ch/static/img/forbidden.png)
UNIL restricted access
State: Public
Version: Final published version
License: Not specified
Serval ID
serval:BIB_7F760B56263B
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Stimulation of the dorsolateral prefrontal cortex modulates brain cue reactivity to reward (un)availability
Journal
Cortex
ISSN
0010-9452
Publication state
Published
Issued date
2023
Peer-reviewed
Oui
Volume
164
Pages
51-62
Language
english
Abstract
Brain imaging studies have shown that stimulation of the left dorsolateral prefrontal cortex (dlPFC), which plays a pivotal role in high-order cognitive control processes, modulates brain reactivity to reward-related cues. Nevertheless, the impact of contextual factors such as reward availability (the reward that is depicted in the cue exposure task) on such modulation effect remains unclear. Here we tested whether a single session of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the left dlPFC differently impacts brain reactivity to cues signalling either availability or unavailability of a sports betting opportunity. Employing a within-subject design (verum versus sham HF-rTMS) among thirty-two frequent sports bettors, we first observed that, as compared to the sham condition, verum HF-rTMS modulated brain reactivity to game cues prior to being made (un)available for betting, through simultaneous increases (posterior insula and caudate nucleus) and decreases (occipital pole) in brain activation. Second, verum HF-rTMS led to increased ventral striatal activity towards cues available for betting but did not modulate brain response to cues unavailable for betting. Taken together, these findings demonstrate that transient stimulation of the left dlPFC led to a general modulation in brain activity in responses to cues, and that this effect is only partly dependent on cues signalling for reward (un)availability.
Keywords
rTMS, fMRI, Cue reactivity, Reward availability, Dorsolateral prefrontal cortex, Ventral striatum
Pubmed
Web of science
Create date
10/05/2023 22:57
Last modification date
01/07/2023 6:48