Comparison of 123I-MIBG SPECT-CT and 18F-DOPA PET-CT in the evaluation of patients with known or suspected recurrent paraganglioma.
Details
Serval ID
serval:BIB_7F6E109FCAE1
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Comparison of 123I-MIBG SPECT-CT and 18F-DOPA PET-CT in the evaluation of patients with known or suspected recurrent paraganglioma.
Journal
Nuclear medicine communications
ISSN
1473-5628 (Electronic)
ISSN-L
0143-3636
Publication state
Published
Issued date
07/2011
Peer-reviewed
Oui
Volume
32
Number
7
Pages
575-582
Language
english
Notes
Publication types: Comparative Study ; Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Detection of recurrent disease is essential for treatment planning in patients with paraganglioma. The aim of this study was to compare 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy [whole-body and single-photon emission computed tomography (SPECT) computed tomography (CT) scanning] and fluorine-18-L-dihydroxyphenylalanine positron emission tomography CT (18F-DOPA PET-CT) in the re-staging of patients with known or suspected recurrent paraganglioma.
Twelve patients with known or suspected recurrent paraganglioma after initial surgery were included in the study. 18F-DOPA PET-CT and 123I-MIBG scintigraphy (whole-body and SPECT-CT scanning) were performed in all patients; the results were compared on a per patient and a per lesion basis. Cytohistology (when available) and a combination of laboratory and imaging studies and follow-up were used as reference standard; any modification in treatment planning was recorded. In all cases recurrent disease (local or distant) was confirmed by cytohistology (four cases) or at subsequent follow-up (eight cases).
All patients had positive 18F-DOPA studies (100% sensitivity) whereas nine had positive 123I-MIBG studies (75% sensitivity; P=not significant). 18F-DOPA detected 98% of lesions, whereas 38% were detected with 123I-MIBG (P=0.04). 18F-DOPA showed more lesions than 123I-MIBG in eight patients; both techniques showed the same number of lesions in two cases whereas in two patients 123I-MIBG showed a greater number of lesions. A change in treatment planning was suggested by 18F-DOPA in one patient.
These data support the superiority of 18F-DOPA PET-CT over 123I-MIBG scintigraphy to assess disease extension in patients with recurrent paraganglioma; however, in cases with inoperable disease, 123I-MIBG maintains a unique role in allowing the selection of patients suitable for 123I-MIBG therapy.
Twelve patients with known or suspected recurrent paraganglioma after initial surgery were included in the study. 18F-DOPA PET-CT and 123I-MIBG scintigraphy (whole-body and SPECT-CT scanning) were performed in all patients; the results were compared on a per patient and a per lesion basis. Cytohistology (when available) and a combination of laboratory and imaging studies and follow-up were used as reference standard; any modification in treatment planning was recorded. In all cases recurrent disease (local or distant) was confirmed by cytohistology (four cases) or at subsequent follow-up (eight cases).
All patients had positive 18F-DOPA studies (100% sensitivity) whereas nine had positive 123I-MIBG studies (75% sensitivity; P=not significant). 18F-DOPA detected 98% of lesions, whereas 38% were detected with 123I-MIBG (P=0.04). 18F-DOPA showed more lesions than 123I-MIBG in eight patients; both techniques showed the same number of lesions in two cases whereas in two patients 123I-MIBG showed a greater number of lesions. A change in treatment planning was suggested by 18F-DOPA in one patient.
These data support the superiority of 18F-DOPA PET-CT over 123I-MIBG scintigraphy to assess disease extension in patients with recurrent paraganglioma; however, in cases with inoperable disease, 123I-MIBG maintains a unique role in allowing the selection of patients suitable for 123I-MIBG therapy.
Keywords
3-Iodobenzylguanidine, Adrenal Gland Neoplasms/diagnosis, Adrenal Gland Neoplasms/pathology, Adrenal Gland Neoplasms/surgery, Adult, Aged, Dihydroxyphenylalanine/analogs & derivatives, Female, Humans, Male, Middle Aged, Neoplasm Staging, Paraganglioma/diagnosis, Paraganglioma/pathology, Paraganglioma/surgery, Paraganglioma, Extra-Adrenal/diagnosis, Paraganglioma, Extra-Adrenal/pathology, Paraganglioma, Extra-Adrenal/surgery, Pheochromocytoma/diagnosis, Pheochromocytoma/pathology, Pheochromocytoma/surgery, Positron-Emission Tomography/methods, Recurrence, Retrospective Studies, Tomography, Emission-Computed, Single-Photon/methods, Tomography, X-Ray Computed/methods, Young Adult
Pubmed
Web of science
Create date
20/08/2017 21:20
Last modification date
20/08/2019 14:40