The dietary triterpenoid 18α-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.

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Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_7F64F6BCDA11
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The dietary triterpenoid 18α-Glycyrrhetinic acid protects from MMC-induced genotoxicity through the ERK/Nrf2 pathway.
Journal
Redox biology
Author(s)
Lefaki M., Papaevgeniou N., Tur J.A., Vorgias C.E., Sykiotis G.P., Chondrogianni N.
ISSN
2213-2317 (Electronic)
ISSN-L
2213-2317
Publication state
Published
Issued date
01/2020
Peer-reviewed
Oui
Volume
28
Pages
101317
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid that has been shown to activate the nuclear factor (erythroid-derived-2)-like 2 (Nrf2), the main transcription factor that orchestrates the cellular antioxidant response, in both cellular and organismal context. Although various beneficial properties of 18α-GA have been revealed, including its anti-oxidation and anti-aging activity, its possible protective effect against DNA damage has never been addressed. In this study, we investigated the potential beneficial properties of 18α-GA against DNA damage induced by mitomycin C (MMC) treatment. Using human primary fibroblasts exposed to MMC following pre-treatment with 18α-GA, we reveal an Nrf2-mediated protective effect against MMC-induced cell death that depends on extracellular signal-regulated kinase (ERK) signaling. In total, our results reveal an additional beneficial effect of the Nrf2 activator 18α-GA, suggesting that this important phytochemical compound is a potential candidate in preventive and/or therapeutic schemes against conditions (such as aging) or diseases that are characterized by both oxidative stress and DNA damage.
Keywords
18α–Glycyrrhetinic acid, DNA damage, ERK pathway, Mitomycin C, Nrf2, Phytochemicals
Pubmed
Web of science
Open Access
Yes
Funding(s)
Fondation Leenaards / 2016 Fellowship for Academic Promotion in Clinical Medicine
Swiss National Science Foundation / Projects / 31003A_182105
Swiss National Science Foundation / IZCOZ0-177070
Create date
13/09/2019 10:43
Last modification date
05/01/2020 6:18
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