Measures to control blood activation during assisted circulation.

Details

Serval ID
serval:BIB_7F55187B7BB5
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Measures to control blood activation during assisted circulation.
Journal
The Annals of thoracic surgery
Author(s)
Baufreton C., Kirsch M., Loisance D.Y.
ISSN
0003-4975 (Print)
ISSN-L
0003-4975
Publication state
Published
Issued date
11/1998
Peer-reviewed
Oui
Volume
66
Number
5
Pages
1837-1844
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Major improvements in heart assist devices have allowed prolonged mechanical circulatory support with successful subsequent weaning or heart transplantation. The contact of blood with biomaterials used in life-sustaining devices and numerous biomaterial-independent factors elicit a systemic inflammatory response, which involves activation of various plasma protein systems and blood cells. Prolonged mechanical circulatory support elicits a systemic inflammatory response and hemostatic perturbations similar to that reported during cardiopulmonary bypass. However, in the setting of prolonged assistance, time has a complex and ill-known influence on blood activation. Methods to reduce blood activation during prolonged assisted circulation are derived from cardiopulmonary bypass investigations. Improving the biocompatibility of artificial devices can be achieved either by biomaterial surface modifications, by inhibition of biologic cascades leading to blood activation, or by controlling end points of biologic cascades. However, the necessity to respect the integrity of the organism during prolonged assistance precludes most systemic interventions and limits the control of blood activation to the area of the device.
Keywords
Assisted Circulation, Biocompatible Materials, Blood Physiological Phenomena, Complement System Proteins/physiology, Endothelium, Vascular/cytology, Heart-Assist Devices, Humans, Monocytes/physiology, Platelet Activation/physiology
Pubmed
Web of science
Create date
30/03/2019 17:12
Last modification date
20/08/2019 14:40
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