Extensive gene traffic on the mammalian X chromosome.

Details

Serval ID
serval:BIB_7EF7D0855D09
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Extensive gene traffic on the mammalian X chromosome.
Journal
Science
Author(s)
Emerson J.J., Kaessmann H., Betrán E., Long M.
ISSN
1095-9203[electronic]
Publication state
Published
Issued date
2004
Peer-reviewed
Oui
Volume
303
Number
5657
Pages
537-540
Language
english
Abstract
Mammalian sex chromosomes have undergone profound changes since evolving from ancestral autosomes. By examining retroposed genes in the human and mouse genomes, we demonstrate that, during evolution, the mammalian X chromosome has generated and recruited a disproportionately high number of functional retroposed genes, whereas the autosomes experienced lower gene turnover. Most autosomal copies originating from X-linked genes exhibited testis-biased expression. Such export is incompatible with mutational bias and is likely driven by natural selection to attain male germline function. However, the excess recruitment is consistent with a combination of both natural selection and mutational bias.
Keywords
Animals, Chromosomes, Human, Chromosomes, Human, X, Chromosomes, Mammalian, Computational Biology, Dosage Compensation, Genetic, Evolution, Female, Gene Expression Profiling, Genes, Duplicate, Genome, Genome, Human, Humans, Introns, Linkage (Genetics), Male, Mice, Monte Carlo Method, Mutation, Oligonucleotide Array Sequence Analysis, Ovary, Pseudogenes, Recombination, Genetic, Retroelements, Selection (Genetics), Sex Characteristics, Testis, X Chromosome
Pubmed
Web of science
Create date
24/01/2008 15:41
Last modification date
20/08/2019 14:39
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