The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection.

Details

Serval ID
serval:BIB_7EF03DE26E06
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
The hourglass model of evolutionary conservation during embryogenesis extends to developmental enhancers with signatures of positive selection.
Journal
Genome research
Author(s)
Liu J., Viales R.R., Khoueiry P., Reddington J.P., Girardot C., Furlong E., Robinson-Rechavi M.
ISSN
1549-5469 (Electronic)
ISSN-L
1088-9051
Publication state
In Press
Peer-reviewed
Oui
Language
english
Notes
Publication types: Journal Article
Publication Status: aheadofprint
Abstract
Inter-species comparisons of both morphology and gene expression within a phylum have revealed a period in the middle of embryogenesis with more similarity between species compared to earlier and later time-points. This "developmental hourglass" pattern has been observed in many phyla, yet the evolutionary constraints on gene expression, and underlying mechanisms of how this is regulated, remains elusive. Moreover, the role of positive selection on gene regulation in the more diverged earlier and later stages of embryogenesis remains unknown. Here, using DNase-seq to identify regulatory regions in two distant Drosophila species (D. melanogaster and D. virilis), we assessed the evolutionary conservation and adaptive evolution of enhancers throughout multiple stages of embryogenesis. This revealed a higher proportion of conserved enhancers at the phylotypic period, providing a regulatory basis for the hourglass expression pattern. Using an in silico mutagenesis approach, we detect signatures of positive selection on developmental enhancers at early and late stages of embryogenesis, with a depletion at the phylotypic period, suggesting positive selection as one evolutionary mechanism underlying the hourglass pattern of animal evolution.
Pubmed
Open Access
Yes
Funding(s)
Swiss National Science Foundation / Projects / 173048
Create date
26/07/2021 10:44
Last modification date
30/07/2021 6:39
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