A novel screen for genes associated with pheromone-induced sterility

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Version: Final published version
Serval ID
serval:BIB_7EDD104D83DB
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A novel screen for genes associated with pheromone-induced sterility
Journal
Scientific Reports
Author(s)
Camiletti A.L., Percival-Smith A., Croft J.R., Thompson G.J.
ISSN
2045-2322 (electronic)
Publication state
Published
Issued date
2016
Peer-reviewed
Oui
Volume
6
Pages
36041
Language
english
Abstract
For honey bee and other social insect colonies the 'queen substance' regulates colony reproduction rendering workers functionally sterile. The evolution of worker reproductive altruism is explained by inclusive fitness theory, but little is known of the genes involved or how they regulate the phenotypic expression of altruism. We previously showed that application of honeybee queen pheromone to virgin fruit flies suppresses fecundity. Here we exploit this finding to identify genes associated with the perception of an ovary-inhibiting social pheromone. Mutational and RNAi approaches in Drosophila reveal that the olfactory co-factor Orco together with receptors Or49b, Or56a and Or98a are potentially involved in the perception of queen pheromone and the suppression of fecundity. One of these, Or98a, is known to mediate female fly mating behaviour, and its predicted ligand is structurally similar to a methyl component of the queen pheromone. Our novel approach to finding genes associated with pheromone-induced sterility implies conserved reproductive regulation between social and pre-social orders, and further helps to identify candidate orthologues from the pheromone-responsive pathway that may regulate honeybee worker sterility.
Pubmed
Web of science
Open Access
Yes
Create date
31/10/2016 15:12
Last modification date
20/08/2019 14:39
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