Adjuvant chemoradiation for gastric carcinoma: State of the art and perspectives.

Details

Serval ID
serval:BIB_7ECF9D2A7768
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Adjuvant chemoradiation for gastric carcinoma: State of the art and perspectives.
Journal
Clinical and translational radiation oncology
Author(s)
Schernberg A., Rivin Del Campo E., Rousseau B., Matzinger O., Loi M., Maingon P., Huguet F.
ISSN
2405-6308 (Electronic)
ISSN-L
2405-6308
Publication state
Published
Issued date
03/2018
Peer-reviewed
Oui
Volume
10
Pages
13-22
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Abstract
An estimated 990,000 new cases of gastric cancer are diagnosed worldwide each year. Surgical excision, the only chance for prolonged survival, is feasible in about 20% of cases. Even after surgery, the median survival is limited to 12 to 20 months due to the frequency of locoregional and/or metastatic recurrences. This led to clinical trials associating surgery with neoadjuvant or adjuvant treatments to improve tumor control and patient survival. The most studied modalities are perioperative chemotherapy and adjuvant chemoradiotherapy. To date, evidence has shown a survival benefit for postoperative chemoradiotherapy and for perioperative chemotherapy. Phase III trials are ongoing to compare these two modalities. The aim of this review is to synthesize current knowledge about adjuvant chemoradiotherapy in the management of gastric adenocarcinoma, and to consider its prospects by integrating modern radiotherapy techniques.
Keywords
5FU, 5-fluorouracil, 5FU-LV, 5-fluorouracil leucovorin, Adenocarcinoma, Adjuvant therapy, CRT, chemoradiotherapy, CT, chemotherapy, Chemoradiotherapy, DCF, Doxorubicin Cisplatin 5-fluorouracil, ECF, Epirubicin Cisplatin 5-fluorouracil, ECX, Epirubicin Cisplatin Capecitabin, FOLFOX, 5-fluorouracil oxaliplatin, FUFOL, bolus 5-fluorouracil followed by leucovorin over 15 minutes, Gastric cancer, IMRT, IMRT, intensity modulated radiation therapy, LV, leucovorin, RT, radiation therapy, XELOX, capecitabin oxaliplatine
Pubmed
Open Access
Yes
Create date
14/12/2018 10:47
Last modification date
20/08/2019 14:39
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