History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium.

Details

Ressource 1Request a copy Sous embargo indéterminé.
State: Public
Version: Final published version
Secondary document(s)
Download: 22144496_Postprint.pdf (643.90 [Ko])
State: Public
Version: author
Serval ID
serval:BIB_7EB71E545DC7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
History of diabetes and risk of head and neck cancer: a pooled analysis from the international head and neck cancer epidemiology consortium.
Journal
Cancer Epidemiology, Biomarkers and Prevention
Author(s)
Chen Chu, Chuang Shu-Chun, Lee Yuan-Chin Amy, Boccia Stefania, Brenner Hermann, Cadoni Gabriela, Dal Maso Luigino, La Vecchia Carlo, Lazarus Philip, Levi Fabio, Matsuo Keitaro, Morgenstern Hal, Müller Heiko, Muscat Joshua, Olshan Andrew F., Purdue Mark P., Serraino Diego, Vaughan Thomas L., Zhang Zuo-Feng, Boffetta Paolo, Hashibe Mia, Schwartz Stephen M.
ISSN
1538-7755 (Electronic)
ISSN-L
1055-9965
Publication state
Published
Issued date
2012
Peer-reviewed
Oui
Volume
21
Number
2
Pages
294-304
Language
english
Abstract
BACKGROUND: A history of diabetes is associated with an increased risk of several types of cancers. Whether diabetes is a risk factor for head and neck cancer (HNC) has received little attention. METHODS: We pooled data from 12 case-control studies including 6,448 cases and 13,747 controls, and estimated odds ratios (OR) and 95% confidence intervals (CI) for the associations between diabetes and HNC, adjusted for age, education level, sex, race/ethnicity, study center, cigarette smoking, alcohol use and body mass index (BMI). RESULTS: We observed a weak association between diabetes and the incidence of HNC overall (OR, 1.09; 95% CI, 0.95-1.24). However, we observed a modest association among never smokers (OR, 1.59; 95% CI, 1.22-2.07), and no association among ever smokers (OR, 0.96; 95% CI, 0.83-1.11); likelihood ratio test for interaction p=0.001. CONCLUSIONS: A history of diabetes was weakly associated with HNC overall, but we observed evidence of effect modification by smoking status, with a positive association among those who never smoked cigarettes. Impact: This study suggests that glucose metabolism abnormalities may be a HNC risk factor in subgroups of the population. Prospective studies incorporating biomarkers are needed to improve our understanding of the relationship between diabetes and HNC risk, possibly providing new strategies in the prevention of HNC.
Pubmed
Web of science
Open Access
Yes
Create date
07/12/2011 16:29
Last modification date
20/08/2019 15:39
Usage data