Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. III. Changes following ischaemia.

Details

Serval ID
serval:BIB_7E9FD54DE6EE
Type
Article: article from journal or magazin.
Collection
Publications
Title
Acute cerebral ischaemia: concurrent changes in cerebral blood flow, energy metabolites, pH, and lactate measured with hydrogen clearance and 31P and 1H nuclear magnetic resonance spectroscopy. III. Changes following ischaemia.
Journal
Journal of Cerebral Blood Flow and Metabolism
Author(s)
Allen K., Busza A.L., Crockard H.A., Frackowiak R.S., Gadian D.G., Proctor E., Russell R.W., Williams S.R.
ISSN
0271-678X (Print)
ISSN-L
0271-678X
Publication state
Published
Issued date
1988
Volume
8
Number
6
Pages
816-821
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Abstract
CBF has been measured with the hydrogen clearance technique in the two cerebral hemispheres of the gerbil under halothane anaesthesia. At the same time, intracellular pH and the concentrations of lactate and high-energy phosphates were measured in the brain using 1H and 31P nuclear magnetic resonance spectroscopy. Flow and metabolism have been followed during either a 15- or a 30-min ischaemic period (induced by bilateral carotid occlusion) and for up to 1 h of recovery. There was no significant difference between the flow characteristics of the two experimental groups. High-energy phosphate levels and pH returned to control within approximately 20 min of the end of the ischaemic period. Lactate clearance, following a 30-min occlusion, was slower than the recovery of pH. The concentration of free ADP, calculated from the creatine kinase equilibrium, was lower during the recovery phase than under control conditions.
Keywords
Animals, Brain/metabolism, Brain Ischemia/metabolism, Brain Ischemia/physiopathology, Cerebrovascular Circulation, Energy Metabolism, Gerbillinae, Hydrogen/metabolism, Hydrogen-Ion Concentration, Lactates/metabolism, Lactic Acid, Magnetic Resonance Spectroscopy, Male, Metabolic Clearance Rate, Phosphorus/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
08/10/2011 14:15
Last modification date
20/08/2019 14:39
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