A comparison of different bivariate correlated frailty models and estimation strategies

Details

Serval ID
serval:BIB_7E89A4C94E13
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A comparison of different bivariate correlated frailty models and estimation strategies
Journal
Mathematical Biosciences
Author(s)
Wienke Andreas, Arbeev Konstantin G., Locatelli Isabella, Yashin Anatoli I.
ISSN
0025-5564
Publication state
Published
Issued date
2005
Volume
198
Number
1
Pages
1-13
Notes
SAPHIRID:58628
Abstract
Frailty models are becoming increasingly popular in multivariate survival analysis. Shared frailty models in particular are often used despite their limitations. To overcome their disadvantages numerous correlated frailty models were established during the last decade. In the present study, we examine bivariate correlated frailty models, and especially the behavior of the parameter estimates when using different estimation strategies. We consider three different bivariate frailty models: the gamma model and two versions of the log-normal model. The traditional maximum likelihood procedure of parameter estimation in the gamma case with an explicit available likelihood function is compared with maximum likelihood methods based on numerical integration and a Bayesian approach using MCMC methods with the help of a comprehensive simulation study. We detected a strong dependence between the two parameter estimates (variance and correlation of frailties) in the bivariate correlated frailty model and analyzed this dependence in detail. [Authors]
Keywords
Bayes Theorem , Likelihood Functions , Models, Statistical , Multivariate Analysis , Survival Analysis
Pubmed
Web of science
Create date
05/03/2008 9:28
Last modification date
20/08/2019 14:39
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