A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).

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State: Public
Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_7E6BA5C7154A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
A community proposal to integrate structural bioinformatics activities in ELIXIR (3D-Bioinfo Community).
Journal
F1000Research
Author(s)
Orengo C., Velankar S., Wodak S., Zoete V., Bonvin AMJJ, Elofsson A., Feenstra K.A., Gerloff D.L., Hamelryck T., Hancock J.M., Helmer-Citterich M., Hospital A., Orozco M., Perrakis A., Rarey M., Soares C., Sussman J.L., Thornton J.M., Tuffery P., Tusnady G., Wierenga R., Salminen T., Schneider B.
ISSN
2046-1402 (Electronic)
ISSN-L
2046-1402
Publication state
Published
Issued date
2020
Peer-reviewed
Oui
Volume
9
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Abstract
Structural bioinformatics provides the scientific methods and tools to analyse, archive, validate, and present the biomolecular structure data generated by the structural biology community. It also provides an important link with the genomics community, as structural bioinformaticians also use the extensive sequence data to predict protein structures and their functional sites. A very broad and active community of structural bioinformaticians exists across Europe, and 3D-Bioinfo will establish formal platforms to address their needs and better integrate their activities and initiatives. Our mission will be to strengthen the ties with the structural biology research communities in Europe covering life sciences, as well as chemistry and physics and to bridge the gap between these researchers in order to fully realize the potential of structural bioinformatics. Our Community will also undertake dedicated educational, training and outreach efforts to facilitate this, bringing new insights and thus facilitating the development of much needed innovative applications e.g. for human health, drug and protein design. Our combined efforts will be of critical importance to keep the European research efforts competitive in this respect. Here we highlight the major European contributions to the field of structural bioinformatics, the most pressing challenges remaining and how Europe-wide interactions, enabled by ELIXIR and its platforms, will help in addressing these challenges and in coordinating structural bioinformatics resources across Europe. In particular, we present recent activities and future plans to consolidate an ELIXIR 3D-Bioinfo Community in structural bioinformatics and propose means to develop better links across the community. These include building new consortia, organising workshops to establish data standards and seeking community agreement on benchmark data sets and strategies. We also highlight existing and planned collaborations with other ELIXIR Communities and other European infrastructures, such as the structural biology community supported by Instruct-ERIC, with whom we have synergies and overlapping common interests.
Keywords
ELIXIR, Instruct-ERIC, biomolecular structure, nucleic acids structure, protein structure, structural bioinformatics
Pubmed
Open Access
Yes
Create date
03/07/2020 18:47
Last modification date
15/01/2021 7:10
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