Development of a vaccine against Helicobacter pylori infection

Details

Serval ID
serval:BIB_7E3E1B30DF39
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Development of a vaccine against Helicobacter pylori infection
Journal
Italian Journal of Gastroenterology and Hepatology
Author(s)
Michetti  P.
ISSN
1125-8055 (Print)
Publication state
Published
Issued date
10/1998
Volume
30 Suppl 3
Pages
S339-41
Notes
Comparative Study
Journal Article
Review --- Old month value: Oct
Abstract
In animals, oral immunization can prevent or cure Helicobacter pylori infection, and prevent reinfection. Several antigens of the pathogen have been identified as protective antigens, and some appear to be well suited for use in an human vaccine. Initial clinical studies have shown that urease is safe in humans, and immunogenic in Helicobacter pylori-infected volunteers. The design of a protective vaccine in humans will probably depend upon the combination of two or more antigens, the identification of the optimal route of immunization, and the use of appropriate vaccine delivery systems. Because a vaccine against Helicobacter pylori is likely to be effective regardless of the mode of transmission of the infection, it represents a potential alternative to current therapies, with the added advantage of having a direct impact on the reservoir of the infection.
Keywords
Animals Antigens, Bacterial/immunology Bacterial Vaccines/*therapeutic use Ferrets Gastric Mucosa/immunology/microbiology Gastritis/microbiology/prevention & control Helicobacter Infections/microbiology/*prevention & control Helicobacter pylori/*immunology Humans Mice Primates Recurrence/prevention & control Treatment Outcome
Pubmed
Web of science
Create date
25/01/2008 16:02
Last modification date
20/08/2019 14:39
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