Re-education of macrophages as a therapeutic strategy in cancer.

Details

Ressource 1Download: 31088236.pdf (1340.79 [Ko])
State: Public
Version: Final published version
License: CC BY-NC-ND 4.0
Serval ID
serval:BIB_7E2B9DDA760A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Re-education of macrophages as a therapeutic strategy in cancer.
Journal
Immunotherapy
Author(s)
Kowal J., Kornete M., Joyce J.A.
ISSN
1750-7448 (Electronic)
ISSN-L
1750-743X
Publication state
Published
Issued date
06/2019
Peer-reviewed
Oui
Volume
11
Number
8
Pages
677-689
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Tumor-associated macrophages (TAMs) can be educated within the tumor microenvironment to promote cancer development and progression. While TAM-targeted agents have largely focused on macrophage depletion as an anticancer strategy, it is becoming increasingly evident that TAM re-education may represent a more effective approach. In this perspective, we discuss different means to achieve TAM re-education, and review the beneficial effects of these strategies, particularly when combined with immune checkpoint inhibitors.
Keywords
Animals, Humans, Immunotherapy, Macrophages/immunology, Macrophages/pathology, Neoplasms/immunology, Neoplasms/pathology, Neoplasms/therapy, Tumor Microenvironment/immunology, anticancer treatment, cancer immunotherapy, macrophages, tumor microenvironment, tumor-associated macrophages
Pubmed
Web of science
Open Access
Yes
Create date
03/06/2019 8:15
Last modification date
27/04/2020 6:20
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