Haemodynamic and pharmacological effects of the converting enzyme inhibitor CGS 14824A in normal volunteers

Details

Serval ID
serval:BIB_7E10E21A51CA
Type
Article: article from journal or magazin.
Collection
Publications
Title
Haemodynamic and pharmacological effects of the converting enzyme inhibitor CGS 14824A in normal volunteers
Journal
European Journal of Clinical Pharmacology
Author(s)
Schaller  M. D., Nussberger  J., Waeber  B., Bussien  J. P., Turini  G. A., Brunner  H., Brunner  H. R.
ISSN
0031-6970 (Print)
Publication state
Published
Issued date
1985
Volume
28
Number
3
Pages
267-72
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
The converting enzyme inhibitor CGS 14824A was evaluated in 15 healthy male volunteers. First, the efficacy of a single 5 or 10 mg oral dose in antagonizing the pressor response to exogenous angiotensin I was tested in 2 subjects. Blood pressure and heart rate were monitored continuously through an intra-arterial catheter. CGS 14824A 5 mg reduced the response to angiotensin I within 75 min to 50%, and 10 mg within 1 h to less than 25%, and for a period of more than 4 h. Subsequently, plasma renin and converting enzyme activity, plasma angiotensin I, angiotensin II and aldosterone were measured serially before and up to 72 h following oral administration of 2, 5, 10 or 20 mg CGS 14824A to groups of 5 volunteers. Plasma converting enzyme activity fell to well below 10% of baseline within 1 h after administration of 5 mg or more CGS 14824A. Within 2 h following 2 mg p.o., a similarly low level was reached. Twenty four hours following the 20 mg dose, plasma converting enzyme activity was still below 10%. As expected, plasma renin activity and angiotensin I rose while angiotensin II and aldosterone fell following the 2 mg dose. This pattern of effects was enhanced by increasing the dose. Nonetheless, 24 h after the 20 mg dose, plasma angiotensin II and aldosterone had returned to their baseline levels. No side-effects occurred. Thus, in normal volunteers, CGS 14824A was an effective, potent and long acting converting enzyme inhibitor.
Keywords
Adult Angiotensin II/blood *Angiotensin-Converting Enzyme Inhibitors Benzazepines/*pharmacology Hemodynamic Processes/*drug effects Humans Male Renin/blood
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 14:39
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