Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
Details
Serval ID
serval:BIB_7E0D5B9320FC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
Journal
Arthritis Research
ISSN
1465-9905 (Print)
Publication state
Published
Issued date
2000
Volume
2
Number
6
Pages
504-12
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Abstract
STATEMENT OF FINDINGS: We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.
Keywords
Animals
Antithrombin III/metabolism
Arthritis, Rheumatoid/*genetics/physiopathology
Blood Coagulation/*genetics
Collagen
Fibrinolysis/*genetics
Gene Expression Regulation/physiology
Male
Mice
Mice, Inbred C57BL
Mice, Inbred DBA
RNA, Messenger/analysis
Synovial Membrane/metabolism
Thrombin/metabolism
Thromboplastin/genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 9:38
Last modification date
20/08/2019 15:39