Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis

Details

Serval ID
serval:BIB_7E0D5B9320FC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis
Journal
Arthritis Research
Author(s)
Salvi  R., Peclat  V., So  A., Busso  N.
ISSN
1465-9905 (Print)
Publication state
Published
Issued date
2000
Volume
2
Number
6
Pages
504-12
Notes
Journal Article
Research Support, Non-U.S. Gov't
Abstract
STATEMENT OF FINDINGS: We have analyzed the pattern of procoagulant and fibrinolytic gene expression in affected joints during the course of arthritis in two murine models. In both models, we found an increased expression of tissue factor, tissue factor pathway inhibitor, urokinase plasminogen activator, and plasminogen activator inhibitor 1, as well as thrombin receptor. The observed pattern of gene expression tended to favor procoagulant activity, and this pattern was confirmed by functional assays. These alterations would account for persistence of fibrin within the inflamed joint, as is seen in rheumatoid arthritis.
Keywords
Animals Antithrombin III/metabolism Arthritis, Rheumatoid/*genetics/physiopathology Blood Coagulation/*genetics Collagen Fibrinolysis/*genetics Gene Expression Regulation/physiology Male Mice Mice, Inbred C57BL Mice, Inbred DBA RNA, Messenger/analysis Synovial Membrane/metabolism Thrombin/metabolism Thromboplastin/genetics
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 8:38
Last modification date
20/08/2019 14:39
Usage data