Ventricular assist with heparin surface coated devices

Details

Serval ID
serval:BIB_7E0A5A27B3EE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Ventricular assist with heparin surface coated devices
Journal
ASAIO Transactions
Author(s)
von Segesser  L. K., Weiss  B. M., Bisang  B., Leskosek  B., Turina  M. I.
ISSN
1058-2916
0889-7190
Publication state
Published
Issued date
09/1991
Volume
37
Number
3
Pages
M278-9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul-Sep
Abstract
Heparin surface coated ventricular assist devices (VADs) were evaluated without systemic heparinization and compared with uncoated control VADs with systemic heparinization (bovine experiments, n = 8; bodyweight, 75 +/- 6 kg). No heparin was given in the study group, whereas heparin (300 IU/kg) was given before cannulation in the control group. Mean activated clotting time (ACT) was 127 +/- 12 sec before and 122 +/- 17 sec after 6 hours of left ventricular assist for coated (NS) versus 184 +/- 114 sec before and 650 +/- 240 sec after for uncoated (p less than 0.05) VADs. No difference was observed in platelet depletion, plasma hemoglobin, lactic dehydrogenase (LDH) production, mixed venous oxygen saturation, and VAD clot score. No VAD occlusions occurred. Ventricular assist can be achieved without systemic heparinization if VADs are improved.
Keywords
Animals Cattle *Heart-Assist Devices Hematocrit Hemoglobinometry *Heparin/administration & dosage L-Lactate Dehydrogenase/blood Microscopy, Electron, Scanning Prosthesis Design Surface Properties
Pubmed
Create date
14/02/2008 14:18
Last modification date
20/08/2019 14:39
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