Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia

Details

Serval ID
serval:BIB_7DE5F0F7E974
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Expression of BPI (bactericidal/permeability-increasing protein) in human mucosal epithelia
Journal
Biochemical Society Transactions
Author(s)
Levy O., Canny G., Serhan C. N., Colgan S. P.
ISSN
0300-5127
Publication state
Published
Issued date
08/2003
Peer-reviewed
Oui
Volume
31
Number
Pt 4
Pages
795-800
Notes
Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review --- Old month value: Aug
Abstract
Among the antimicrobial proteins and peptides of humans is the cationic 55 kDa bactericidal/permeability-increasing protein (BPI), which possesses antibacterial, endotoxin-neutralizing and opsonic activity against Gram-negative bacteria. Although identified originally as an abundant constituent of neutrophil granules, we have recently identified functional expression of BPI by human mucosal epithelia. BPI expression was markedly up-regulated by exposure of epithelia to lipoxins, endogenous anti-inflammatory eicosanoids that are generated in vivo in the context of aspirin treatment (aspirin-triggered lipoxins). Epithelial BPI was found to be surface expressed and fully functional, as measured by antibacterial activity against Salmonella typhimurium as well as lipopolysaccharide (LPS; endotoxin)-neutralizing activity. These results suggest a role for BPI as an effector of epithelial antibacterial activity and as a modulator of epithelial responses to LPS. Both BPI and the lipoxins are currently the subject of intensive biopharmaceutical development, raising the possibility that therapeutic use of BPI or modulation of epithelial BPI expression may be a useful adjunctive therapy for conditions in which epithelial inflammation is associated with Gram-negative infections and/or endotoxin.
Keywords
Antimicrobial Cationic Peptides Blood Proteins/*biosynthesis/chemistry/metabolism Epithelial Cells/*metabolism Humans Lipoxins/metabolism *Membrane Proteins Models, Molecular Mucous Membrane/cytology Protein Conformation
Pubmed
Web of science
Create date
18/01/2008 12:11
Last modification date
20/08/2019 14:39
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