Cooperativity in RNA-protein interactions: the complex is more than the sum of its partners.

Details

Serval ID
serval:BIB_7DD9BC1AC6DB
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cooperativity in RNA-protein interactions: the complex is more than the sum of its partners.
Journal
Current opinion in neurobiology
Author(s)
Achsel T., Bagni C.
ISSN
1873-6882 (Electronic)
ISSN-L
0959-4388
Publication state
Published
Issued date
08/2016
Volume
39
Pages
146-151
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Mutations in RNA-binding proteins (RBPs) are often linked to specific neurological disorders, suggesting that each of these RBPs regulates a particular neuronal function. Instead, they recognise many mRNAs and often participate in various post-transcriptional processes. To gain specificity, RBPs bind to RNA in collaboration with other RBPs. This model also explains how an RBP can play diverse roles: many RBPs do not contain an effector domain, which joins the RNA-protein complex as an additional unit. Different complexes, even if anchored on the same RBP, recruit diverse effectors. Therefore, the combination of RBPs determines the fate of an mRNA. We argue that new experimental and bioinformatic paradigms are needed to elucidate the combination of RBPs acting on a given mRNA.

Pubmed
Create date
24/03/2017 9:28
Last modification date
21/08/2019 6:33
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