Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors

Details

Serval ID
serval:BIB_7DD4A959B678
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors
Journal
Ophthalmology
Author(s)
Holz  F. G., Wolfensberger  T. J., Piguet  B., Gross-Jendroska  M., Wells  J. A., Minassian  D. C., Chisholm  I. H., Bird  A. C.
ISSN
0161-6420 (Print)
Publication state
Published
Issued date
09/1994
Volume
101
Number
9
Pages
1522-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Abstract
BACKGROUND: In patients with unilateral visual loss related to age-related macular disease, the risk of visual loss in the second eye is documented as being between 7% and 10% per year. The risk is uncertain in those with good vision with each eye and bilateral macular drusen. METHODS: In a prospective study, 126 patients with bilateral drusen were reviewed annually for up to 3 years. Serial fundus photographs and fluorescein angiograms were analyzed independently by two readers in a masked fashion using a standardized grading scheme, including size, number, density, and fluorescence angiographic behavior of drusen. RESULTS: New lesions occurred in one or both eyes of 17 (13.5%) of the 126 patients. The cumulative incidence of exudative or nonexudative lesions was 8.55% at 1 year, at 2 years 16.37%, and 23.52% at 3 years for patients older than 65 years of age. Significant risk factors included the degree of confluence of drusen within 1600 microns of the center of the fovea (P = 0.023), focal hyperpigmentation (P = 0.004), slow choroidal filling (P = 0.023), and focal extrafoveal areas of atrophy of the retinal pigment epithelium (P = 0.042). CONCLUSIONS: The results give an estimate for the incidence of complicating lesions in patients with bilateral drusen and identify those features indicating higher than average risk of visual loss.
Keywords
Aged Aged, 80 and over Choroid/blood supply Female Fluorescein Angiography Fundus Oculi Humans Incidence *Macula Lutea/pathology Macular Degeneration/*complications Male Middle Aged Prognosis Prospective Studies Retinal Drusen/*etiology/pathology Risk Factors Visual Acuity
Pubmed
Web of science
Create date
28/01/2008 13:05
Last modification date
20/08/2019 14:39
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