Vaginal misoprostol enhances intrauterine insemination
Details
Serval ID
serval:BIB_7DBDA7C07D53
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Vaginal misoprostol enhances intrauterine insemination
Journal
Human Reproduction
ISSN
0268-1161
Publication state
Published
Issued date
01/2001
Peer-reviewed
Oui
Volume
16
Number
1
Pages
96-101
Notes
Clinical Trial
Journal Article
Randomized Controlled Trial --- Old month value: Jan
Journal Article
Randomized Controlled Trial --- Old month value: Jan
Abstract
This study examined whether the prostaglandin E(1) analogue misoprostol (400 microgram), when placed vaginally at the time of intrauterine insemination (IUI) improves pregnancy rates. A prospective, placebo-controlled, randomized and double-blind study involving 274 women in 494 IUI cycles resulted in a total of 64 pregnancies (13% per cycle). Misoprostol cycles totalled 253, with 43 pregnancies (17% per cycle), whereas placebo cycles totalled 241, with 21 pregnancies (9% per cycle). The cumulative pregnancy rate with misoprostol treatment was significantly greater than with placebo (P = 0.004, Cox proportional hazards regression). The benefit of misoprostol was seen in clomiphene cycles (14 versus 4%, P = 0.006), and was indicated in FSH cycles (33 versus 15%, borderline significance) and natural cycles (15.6 versus 7.7%, not significant), but was not seen in clomiphene/FSH cycles (18.2 versus 23.5%, not significant). Misoprostol treatment did not increase pain score on the day of IUI (1.1 versus 1.4) and at 1 day post IUI (0.6 versus 0.8). Complications were rare in both groups [six (2%) subject cycles in the misoprostol cycles compared with two (1%) in the placebo group]. It is concluded that the use of vaginal misoprostol may improve the chance for pregnancy in women having IUI in a wide variety of cycle types.
Keywords
Administration, Intravaginal
Adult
Female
Humans
Infertility/*therapy
Insemination, Artificial, Heterologous
*Insemination, Artificial, Homologous
Male
Misoprostol/*administration & dosage
Pregnancy
Pregnancy Outcome
Pubmed
Web of science
Create date
28/02/2008 12:37
Last modification date
20/08/2019 15:39