Human immunodeficiency virus type 1 fitness is a determining factor in viral rebound and set point in chronic infection.

Details

Serval ID
serval:BIB_7D7067051FB7
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Human immunodeficiency virus type 1 fitness is a determining factor in viral rebound and set point in chronic infection.
Journal
Journal of virology
Author(s)
Trkola A., Kuster H., Leemann C., Ruprecht C., Joos B., Telenti A., Hirschel B., Weber R., Bonhoeffer S., Günthard H.F.
ISSN
0022-538X
Publication state
Published
Issued date
2003
Peer-reviewed
Oui
Volume
77
Number
24
Pages
13146-55
Language
english
Notes
Publication types: Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. - Publication Status: ppublish
Abstract
Human immunodeficiency virus type 1 (HIV-1) isolates from 20 chronically infected patients who participated in a structured treatment interruption (STI) trial were studied to determine whether viral fitness influences reestablishment of viremia. Viruses derived from individuals who spontaneously controlled viremia had significantly lower in vitro replication capacities than viruses derived from individuals that did not control viremia after interruption of antiretroviral therapy (ART), and replication capacities correlated with pre-ART and post-STI viral set points. Of note, no clinically relevant improvement of viral loads upon STI occurred. Virus isolates from controlling and noncontrolling patients were indistinguishable in terms of coreceptor usage, genetic subtype, and sensitivity to neutralizing antibodies. In contrast, viruses from controlling patients exhibited increased sensitivity to inhibition by chemokines. Sensitivity to inhibition by RANTES correlated strongly with slower replication kinetics of the virus isolates, suggesting a marked dependency of these virus isolates on high coreceptor densities on the target cells. In summary, our data indicate that viral fitness is a driving factor in determining the magnitude of viral rebound and viral set point in chronic HIV-1 infection, and thus fitness should be considered as a parameter influencing the outcome of therapeutic intervention in chronic infection.
Keywords
Adult, Aged, Anti-HIV Agents, Chronic Disease, Drug Administration Schedule, Drug Therapy, Combination, Female, HIV Infections, HIV-1, Humans, Male, Middle Aged, Reverse Transcriptase Inhibitors, Viremia, Virus Replication
Pubmed
Web of science
Open Access
Yes
Create date
25/01/2008 14:45
Last modification date
20/08/2019 14:38
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