Methodological assessment of HCC literature.

Details

Ressource 1Download: serval:BIB_7D557AAE02D4.P001 (158.39 [Ko])
State: Public
Version: author
License: Not specified
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
Serval ID
serval:BIB_7D557AAE02D4
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Methodological assessment of HCC literature.
Journal
Annals of Oncology
Author(s)
Daniele G., Costa N., Lorusso V., Costa-Maia J., Pache I., Pirisi M.
ISSN
1569-8041 (Electronic)
ISSN-L
0923-7534
Publication state
Published
Issued date
2013
Volume
24
Number
Suppl. 2
Pages
ii6-ii14
Language
english
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: review
Abstract
Despite the fact that the hepatocellular carcinoma (HCC) represents a major health problem, very few interventions are available for this disease, and only sorafenib is approved for the treatment of advanced disease. Of note, only very few interventions have been thoroughly evaluated over time for HCC patients compared with several hundreds in other, equally highly lethal, tumours. Additionally, clinical trials in HCC have often been questioned for poor design and methodological issues. As a consequence, a gap between what is measured in clinical trials and what clinicians have to face in daily practice often occurs. As a result of this scenario, even the most recent guidelines for treatment of HCC patients use low strength evidence to make recommendations. In this review, we will discuss some of the potential methodological issues hindering a rational development of new treatments for HCC patients.
Pubmed
Web of science
Open Access
Yes
Create date
11/07/2013 20:11
Last modification date
25/09/2019 6:09
Usage data