Anti-peripheral nerve antibodies in leprosy patients recognize an epitope shared by the M. leprae 65 kDa heat shock protein.

Details

Serval ID
serval:BIB_7D15393D296A
Type
Article: article from journal or magazin.
Collection
Publications
Title
Anti-peripheral nerve antibodies in leprosy patients recognize an epitope shared by the M. leprae 65 kDa heat shock protein.
Journal
Journal of Autoimmunity
Author(s)
Launois P., N'Diaye M., Sarthou J.L., Millan J., Bach M.A.
ISSN
0896-8411 (Print)
ISSN-L
0896-8411
Publication state
Published
Issued date
1992
Volume
5
Number
6
Pages
745-757
Language
english
Abstract
Binding of leprosy sera to peripheral nerve from different species (mouse, guinea pig and rabbit) was evaluated by ELISA. A majority of sera, whatever the clinical form of leprosy, bind to these antigens. Absorption with Mycobacterium bovis BCG demonstrated that these antibodies recognize cross-reactive epitopes between peripheral nerve and mycobacteria. In immunoblot analysis, both leprosy patient sera and a monoclonal antibody directed at the 65 kDa heat shock protein of M. leprae were shown to react with a heat-shock 67-68 kDa sciatic nerve protein. Binding of the monoclonal antibody to this sciatic nerve antigen was prevented by incubation with lepromatous patient sera, showing that some peripheral nerve epitopes recognized by patient antibodies are shared by the 65 kDa heat shock protein of M. leprae.
Keywords
Animals, Antibodies, Bacterial, Antigens, Bacterial, Autoantibodies, Autoantigens, Cross Reactions, Epitopes, Guinea Pigs, Heat-Shock Proteins/immunology, Humans, Immunoglobulin G, Leprosy/immunology, Mice, Mycobacterium leprae/immunology, Peripheral Nerves/immunology, Rabbits, Species Specificity
Pubmed
Web of science
Create date
28/01/2008 11:06
Last modification date
20/08/2019 14:38
Usage data