Cis-trans interactions of cell surface receptors: biological roles and structural basis.

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Serval ID
serval:BIB_7D095BF6B21B
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Cis-trans interactions of cell surface receptors: biological roles and structural basis.
Journal
Cellular and Molecular Life Sciences
Author(s)
Held W., Mariuzza R.A.
ISSN
1420-9071 (Electronic)
ISSN-L
1420-682X
Publication state
Published
Issued date
2011
Volume
68
Number
21
Pages
3469-3478
Language
english
Abstract
Cell surface receptors bind ligands expressed on other cells (in trans) in order to communicate with neighboring cells. However, an increasing number of cell surface receptors are found to also interact with ligands expressed on the same cell (in cis). These observations raise questions regarding the biological role of such cis interactions. Specifically, it is important to know whether cis and trans binding have distinct functional effects and, if so, how a single cell discriminates between interactions in cis versus trans. Further, what are the structural features that allow certain cell surface receptors to engage ligand both on the same as well as on an apposed cell membrane? Here, we summarize known examples of receptors that display cis-trans binding and discuss the emerging diversity of biological roles played by these unconventional two-way interactions, along with their structural basis.
Keywords
Humans, Killer Cells, Natural/cytology, Killer Cells, Natural/immunology, Major Histocompatibility Complex/immunology, Protein Binding, Protein Structure, Tertiary, Receptors, Cell Surface/chemistry, Receptors, Cell Surface/metabolism, Receptors, Natural Killer Cell/metabolism, Receptors, Notch/chemistry, Receptors, Notch/metabolism
Pubmed
Web of science
Open Access
Yes
Create date
16/02/2012 15:07
Last modification date
01/10/2019 6:18
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