The RIP kinases: crucial integrators of cellular stress

Details

Serval ID
serval:BIB_7C9B6CFC0EAD
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
The RIP kinases: crucial integrators of cellular stress
Journal
Trends in Biochemical Sciences
Author(s)
Meylan  E., Tschopp  J.
ISSN
0968-0004 (Print)
Publication state
Published
Issued date
03/2005
Volume
30
Number
3
Pages
151-9
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review --- Old month value: Mar
Abstract
Since the discovery of the first member ten years ago, the receptor-interacting protein (RIP) family kinases have emerged as essential sensors of cellular stress. The different members integrate both extracellular stress signals transmitted by various cell-surface receptors and signals emanating from intracellular stress. The cascades of events initiated by activated RIPs are complex. Not only are pro-survival, inflammatory and immune responses triggered by RIP kinases via the activation of transcription factors such as NF-kappaB and AP-1, but opposing, death-inducing programs can also be initiated by the RIP kinases. Hence, RIP kinases are crucial regulators of cell survival and cell death.
Keywords
Amino Acid Sequence Animals Apoptosis/physiology Cell Survival/physiology Humans Immunity, Natural Keratinocytes/cytology/enzymology Mice Models, Biological Molecular Sequence Data NF-kappa B/metabolism Protein-Serine-Threonine Kinases/chemistry/genetics/*physiology Sequence Homology, Amino Acid Signal Transduction Tumor Necrosis Factor-alpha/physiology
Pubmed
Web of science
Create date
24/01/2008 15:18
Last modification date
20/08/2019 14:38
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