The effect of age on the microheterogeneous pattern of human myelin basic protein.

Details

Serval ID
serval:BIB_7BFDBC278029
Type
Article: article from journal or magazin.
Collection
Publications
Title
The effect of age on the microheterogeneous pattern of human myelin basic protein.
Journal
Gerontology
Author(s)
Riederer B., Honegger C.G., Tobler H.J., Ulrich J.
ISSN
0304-324X (Print)
ISSN-L
0304-324X
Publication state
Published
Issued date
1984
Volume
30
Number
4
Pages
234-239
Language
english
Abstract
Dry weight, total basic protein and myelin basic protein (MBP) in human corpus callosum tissue were found to be significantly reduced with age, confirming other reports. The heterogeneous patterns of the MBP samples were investigated and could be classified into three groups: a normal one with peak 1 larger than peak 3; an old-age pattern with peak 1 smaller than peak 3; and a pathological pattern with peak 1 greatly reduced. Because peak 1 is the only one which is significantly reduced with age, it is suggested that future investigations could be simplified. The physiological and pathophysiological role of MBP heterogeneity is discussed.
Keywords
Adult, Aged, Aging, Chromatography, Ion Exchange, Corpus Callosum/metabolism, Corpus Callosum/physiology, Electrophoresis, Polyacrylamide Gel, Humans, Middle Aged, Myelin Basic Protein/analysis, Myelin Basic Protein/physiology, Myelin Proteins/analysis
Pubmed
Web of science
Create date
24/01/2008 14:34
Last modification date
20/08/2019 14:37
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