Characterization of dextromoramide (Palfium) abuse by hair analysis in a denied case.

Details

Serval ID
serval:BIB_7BF5B46ABD9B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Characterization of dextromoramide (Palfium) abuse by hair analysis in a denied case.
Journal
International Journal of Legal Medicine
Author(s)
Kintz P., Cirimele V., Edel Y., Tracqui A., Mangin P.
ISSN
0937-9827[print], 0937-9827[linking]
Publication state
Published
Issued date
1995
Volume
107
Number
5
Pages
269-272
Language
english
Abstract
By providing information on exposure to drugs over time, hair analysis is useful in verifying the history of drug use. In a clinical case, where drug abuse was denied, it was possible to identify dextromoramide in the hair of the subject. After acid hydrolysis of the hair with 0.1 M HCl, in the presence of SKF 525A as an internal standard, the drug was extracted at pH 8.4 with chloroform-isopropanol-n-heptane (50:17:33 v/v) and quantified by gas chromatography/mass spectrometry. The hair strands were cut into 3 sections of 2.5 cm, corresponding to a growth period of 2 months. Concentrations were 1.09, 1.93 and 1.48 ng/mg from the root to the end, respectively. This is the first report on dextromoramide testing in human hair.
Keywords
Dextromoramide/analysis, Dextromoramide/pharmacokinetics, Gas Chromatography-Mass Spectrometry, HIV Seropositivity/diagnosis, HIV Seropositivity/metabolism, Hair/chemistry, Hair/metabolism, Heroin Dependence/diagnosis, Heroin Dependence/metabolism, Humans, Male, Opioid-Related Disorders/diagnosis, Opioid-Related Disorders/metabolism, Substance Abuse Detection, Substance Abuse, Intravenous/diagnosis, Substance Abuse, Intravenous/metabolism
Pubmed
Create date
19/10/2010 15:39
Last modification date
20/08/2019 14:37
Usage data