Magnesium supplementation and deoxycorticosterone acetate--salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1

Details

Serval ID
serval:BIB_7BED0D94990E
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Magnesium supplementation and deoxycorticosterone acetate--salt hypertension: effect on arterial mechanical properties and on activity of endothelin-1
Journal
Canadian Journal of Physiology and Pharmacology
Author(s)
Berthon  N., Laurant  P., Hayoz  D., Fellmann  D., Brunner  H. R., Berthelot  A.
ISSN
0008-4212 (Print)
Publication state
Published
Issued date
06/2002
Volume
80
Number
6
Pages
553-61
Notes
In Vitro
Journal Article --- Old month value: Jun
Abstract
The aim of this study was to show whether the decrease in blood pressure induced by Mg supplementation in deoxycorticosterone acetate - salt (DOCA-salt) hypertensive rats is associated with mechanical modifications of blood vessels and (or) changes in tissular production and (or) vasoconstrictor activity to endothelin-1. DOCA-salt treatment increased blood pressure, media thickness, cross-sectional area, and lumen diameter of carotid arteries. Distensibility and incremental elastic modulus versus stress were not altered in carotid arteries, suggesting that the DOCA-salt vessel wall adapts structurally to preserve its blood pressure buffering capacity. Magnesium supplementation attenuated DOCA-salt hypertension. In comparison with normotensive rats, systolic, mean, and pulse pressures were higher whereas diastolic pressure was not different in Mg-supplemented DOCA-salt rats. Magnesium supplementation did not significantly modify the elastic parameters of carotid arteries. In resistance mesenteric arteries, DOCA-salt hypertension induces an inward hypertrophic remodeling. Magnesium supplementation attenuates wall hypertrophy and increases lumen diameter to the normotensive diameter, suggesting a decrease in peripheral resistance. Magnesium supplementation normalizes the altered vasoconstrictor activity of endothelin-1 in mesenteric arteries and attenuates endothelin-1 overproduction in kidney, left ventricle, and aorta of DOCA-salt rats. These findings suggest that Mg supplementation prevents blood pressure elevation by attenuating peripheral resistance and by decreasing hypertrophic effect of endothelin-1 via inhibition of endothelin-1 production.
Keywords
Animals Arteries/metabolism/*physiopathology Blood Pressure/drug effects/physiology Body Weight/drug effects Calcium/blood Carotid Arteries/anatomy & histology/drug effects/physiology *Desoxycorticosterone Diet Endothelin-1/*metabolism/pharmacology Heart Rate/drug effects/physiology Hypertension/chemically induced/metabolism/*physiopathology Magnesium/blood/*pharmacology Male Mesenteric Arteries/anatomy & histology/drug effects/physiology Organ Size/drug effects Rats Rats, Sprague-Dawley Vascular Resistance/drug effects Vasoconstriction/physiology
Pubmed
Web of science
Create date
17/01/2008 16:38
Last modification date
20/08/2019 14:37
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