Nocardiosis is an infection caused by Nocardia spp., presenting as pulmonary, cutaneous, or disseminated disease. It predominantly affects immunocompromised individuals, with organ transplant recipients being particularly vulnerable. The rarity of this infection, combined with diverse clinical presentations and challenging growth in culture, complicates diagnosis. Treatment is prolonged and frequently involves combination therapy. We report a case of disseminated nocardiosis in a renal transplant patient and examine the clinical and microbiological features of three additional cases diagnosed at CHUV among organ transplant recipients, highlighting the complexity of clinical management.