Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression.

Details

Serval ID
serval:BIB_7B9A30AC0F20
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Examining sex differences in neurodevelopmental and psychiatric genetic risk in anxiety and depression.
Journal
PloS one
Author(s)
Martin J., Asjadi K., Hubbard L., Kendall K., Pardiñas A.F., Jermy B., Lewis C.M., Baune B.T., Boomsma D.I., Hamilton S.P., Lucae S., Magnusson P.K., Martin N.G., McIntosh A.M., Mehta D., Mors O., Mullins N., Penninx BWJH, Preisig M., Rietschel M., Jones I., Walters JTR, Rice F., Thapar A., O'Donovan M.
Working group(s)
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Publication state
Published
Issued date
2021
Peer-reviewed
Oui
Volume
16
Number
9
Pages
e0248254
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
Publication Status: epublish
Abstract
Anxiety and depression are common mental health disorders and have a higher prevalence in females. They are modestly heritable, share genetic liability with other psychiatric disorders, and are highly heterogeneous. There is evidence that genetic liability to neurodevelopmental disorders, such as attention deficit hyperactivity disorder (ADHD) is associated with anxiety and depression, particularly in females. We investigated sex differences in family history for neurodevelopmental and psychiatric disorders and neurodevelopmental genetic risk burden (indexed by ADHD polygenic risk scores (PRS) and rare copy number variants; CNVs) in individuals with anxiety and depression, also taking into account age at onset. We used two complementary datasets: 1) participants with a self-reported diagnosis of anxiety or depression (N = 4,178, 65.5% female; mean age = 41.5 years; N = 1,315 with genetic data) from the National Centre for Mental Health (NCMH) cohort and 2) a clinical sample of 13,273 (67.6% female; mean age = 45.2 years) patients with major depressive disorder (MDD) from the Psychiatric Genomics Consortium (PGC). We tested for sex differences in family history of psychiatric problems and presence of rare CNVs (neurodevelopmental and >500kb loci) in NCMH only and for sex differences in ADHD PRS in both datasets. In the NCMH cohort, females were more likely to report family history of neurodevelopmental and psychiatric disorders, but there were no robust sex differences in ADHD PRS or presence of rare CNVs. There was weak evidence of higher ADHD PRS in females compared to males in the PGC MDD sample, particularly in those with an early onset of MDD. These results do not provide strong evidence of sex differences in neurodevelopmental genetic risk burden in adults with anxiety and depression. This indicates that sex may not be a major index of neurodevelopmental genetic heterogeneity, that is captured by ADHD PRS and rare CNV burden, in adults with anxiety and depression.
Pubmed
Web of science
Open Access
Yes
Create date
04/10/2021 14:03
Last modification date
06/11/2021 6:37
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