Causes développementales dans la variabilité de l'efficacité et de la toxicité des antalgiques en pédiatrie [Developmental causes in variability of efficacy and toxicity of analgesics in pediatrics]

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State: Public
Version: Final published version
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Serval ID
serval:BIB_7B8DA6B6FC9A
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Causes développementales dans la variabilité de l'efficacité et de la toxicité des antalgiques en pédiatrie [Developmental causes in variability of efficacy and toxicity of analgesics in pediatrics]
Journal
Revue Médicale Suisse
Author(s)
Diezi M.
ISSN
1660-9379
Publication state
Published
Issued date
2009
Volume
5
Number
191
Pages
390-394
Language
french
Abstract
The intensity of pain perception and its sensibility to analgesic drugs is highly variable and unpredictable between individuals. Drug disposition varies during development due to the physiological maturation of enzymatic systems and physiological processes responsible for the absorption, distribution, elimination and effect at the site of action. Many of those developmental variables are not yet clearly defined, but their consideration is important for avoiding potential risks of ineffective or toxic treatment. Implications of those developmental changes for day-to-day clinical practice depend on the age of the child, on the type of drug, on the underlying disease and on the potential co-administration of other chemicals.
Keywords
Analgesics, Child, Cytochrome P-450 Enzyme System, Humans
Pubmed
Create date
29/05/2009 11:02
Last modification date
20/08/2019 15:37
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