MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications.

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State: Public
Version: Author's accepted manuscript
Serval ID
serval:BIB_7B630506C07A
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
MicroRNAs as therapeutic targets for the treatment of diabetes mellitus and its complications.
Journal
Expert opinion on therapeutic targets
Author(s)
Regazzi R.
ISSN
1744-7631 (Electronic)
ISSN-L
1472-8222
Publication state
Published
Issued date
02/2018
Peer-reviewed
Oui
Volume
22
Number
2
Pages
153-160
Language
english
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Abstract
Diabetes mellitus is a very common metabolic disorder affecting more than 400 million people worldwide. Currently available treatments permit to manage the disease but, in the long term, many patients develop severe micro- and macrovascular complications that decrease life quality and expectancy. Better therapeutic tools to prevent and treat diabetes are therefore urgently needed. Areas covered: MicroRNAs are key regulators of gene expression and central players in a variety of physiological and pathological processes. This review summarizes the role of microRNAs in insulin-secreting cells and in insulin target tissues as well as their involvement in the development of diabetes and its long term complications. Expert opinion: Because of their physicochemical properties and their capacity to regulate a wide range of physiopathological events, microRNAs are attractive therapeutic targets. There is accumulating evidence that approaches permitting to correct the level of specific microRNAs can successfully prevent or treat diabetes and its complications. Pharmacological tools that efficiently modulate the level of microRNAs are already available. However, before these tools can be allowed to integrate the arsenal for the treatment of diabetic patients, new innovative strategies will be needed to achieve selective delivery of these pharmacological principles to the appropriate target cells.
Keywords
Animals, Diabetes Complications/genetics, Diabetes Complications/physiopathology, Diabetes Complications/therapy, Diabetes Mellitus/genetics, Diabetes Mellitus/physiopathology, Diabetes Mellitus/therapy, Humans, Hypoglycemic Agents/pharmacology, Insulin/metabolism, Insulin-Secreting Cells/metabolism, MicroRNAs/genetics, Molecular Targeted Therapy, Aptamer, diabetes mellitus, diabetic complications, exosome, microRNA
Pubmed
Web of science
Open Access
Yes
Create date
10/01/2018 10:11
Last modification date
20/08/2019 15:37
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