Preoperative CT-Based Skeletal Muscle Mass Depletion and Outcomes after Total Laryngectomy.

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Version: Final published version
License: CC BY 4.0
Serval ID
serval:BIB_7B3B3DB948DE
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Preoperative CT-Based Skeletal Muscle Mass Depletion and Outcomes after Total Laryngectomy.
Journal
Cancers
Author(s)
Salati V., Mandralis K., Becce F., Koerfer J., Lambercy K., Simon C., Gorostidi F.
ISSN
2072-6694 (Print)
ISSN-L
2072-6694
Publication state
Published
Issued date
08/07/2023
Peer-reviewed
Oui
Volume
15
Number
14
Pages
3538
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
To assess the role of preoperative CT-based skeletal muscle mass depletion on postoperative clinical outcomes and survival in patients who underwent total laryngectomy for cancer.
Patients operated on between January 2011 and March 2020 were retrospectively included. Skeletal muscle area and intra- and inter-muscular fat accumulation were measured at the third lumbar vertebral level on preoperative CT scans. Skeletal muscle mass depletion was defined based on pre-established cut-off values. Their association with postoperative morbidity, length of stay (LOS), costs, and survival was assessed.
A total of 84 patients were included, of which 37 (44%) had preoperative skeletal muscle mass depletion. The rate of postoperative fistula (23% vs. 35%, p = 0.348), cutaneous cervical dehiscence (17% vs. 11%, p = 0.629), superficial incisional surgical site infections (SSI) (12% vs. 10%, p = 1.000), and unplanned reoperation (38% vs. 37%, p = 1.000) were comparable between the two patient groups. No difference in median LOS was observed (41 vs. 33 days, p = 0.295), nor in treatment costs (119,976 vs. 109,402 CHF, p = 0.585). The median overall survival was comparable between the two groups (3.43 vs. 4.95 years, p = 0.09).
Skeletal muscle mass depletion alone had no significant impact on postoperative clinical outcomes or survival.
Keywords
muscle mass, muscle quality, postoperative outcomes, sarcopenia, skeletal muscle mass depletion, total laryngectomy
Pubmed
Web of science
Open Access
Yes
Create date
03/08/2023 15:56
Last modification date
23/01/2024 8:28
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