Reduction in left ventricular mass in normotensive and spontaneously hypertensive rats given enalapril.

Details

Serval ID
serval:BIB_7B2D145464F0
Type
Article: article from journal or magazin.
Collection
Publications
Title
Reduction in left ventricular mass in normotensive and spontaneously hypertensive rats given enalapril.
Journal
Clinical and Experimental Pharmacology and Physiology
Author(s)
Mooser V., Casley D., Trinder D., Paxton D.L., Johnston C.I.
ISSN
0305-1870 (Print)
ISSN-L
0305-1870
Publication state
Published
Issued date
1991
Volume
18
Number
5
Pages
341-344
Language
english
Notes
Publication types: Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov'tPublication
Abstract
1. To test the hypothesis that the reduction of left ventricular weight (LVW) observed during angiotensin-converting enzyme (ACE) inhibition in rats is mainly a response to decreased cardiac load, the effect of enalapril on LVW and blood pressure (BP) in normotensive Sprague-Dawley (SD) and in spontaneously hypertensive rats (SHR) was compared. 2. Enalapril decreased BP by 10% in SD rats and 21% in SHR; and LVW by 6% in SD rats and 12% in SHR. A close linear correlation between BP and LVW was observed in SD (r = 0.65, n = 24, P less than 0.001) and SHR (r = 0.92, n = 15, P less than 0.001). 3. The effect of enalapril on LVW, when related to BP, was almost identical in SD and SHR, as the average reduction of LVW (microgram/g of bodyweight) per mmHg was 7.7 +/- 1.9 versus 7.5 +/- 0.9 in SD and SHR respectively. 4. These data constitute additional evidence to support the view that, at least under ACE inhibition, reduction in LVW is mainly due to the fall in BP and the decreased cardiac load.
Keywords
Angiotensin-Converting Enzyme Inhibitors/pharmacology, Animals, Blood Pressure/drug effects, Cardiomegaly/chemically induced, Enalapril/blood, Enalapril/pharmacology, Heart/anatomy & histology, Heart/drug effects, Heart Ventricles/anatomy & histology, Heart Ventricles/drug effects, Myocardium/enzymology, Organ Size/drug effects, Rats, Rats, Inbred SHR, Rats, Inbred Strains, Systole/drug effects
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Web of science
Create date
13/10/2013 21:05
Last modification date
20/08/2019 14:37
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