Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.

Details

Serval ID
serval:BIB_7B21AAC3C93B
Type
Article: article from journal or magazin.
Collection
Publications
Title
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
Journal
Circulation
Author(s)
O'Donnell C.J., Kavousi M., Smith A.V., Kardia S.L., Feitosa M.F., Hwang S.J., Sun Y.V., Province M.A., Aspelund T., Dehghan A., Hoffmann U., Bielak L.F., Zhang Q., Eiriksdottir G., van Duijn C.M., Fox C.S., de Andrade M., Kraja A.T., Sigurdsson S., Elias-Smale S.E., Murabito J.M., Launer L.J., van der Lugt A., Kathiresan S., Krestin G.P., Krestin G.P., Herrington D.M., Howard T.D., Liu Y., Post W., Mitchell B.D., O'Connell J.R., Shen H., Shuldiner A.R., Altshuler D., Elosua R., Salomaa V., Schwartz S.M., Siscovick D.S., Voight B.F., Bis J.C., Glazer N.L., Psaty B.M., Boerwinkle E., Heiss G., Blankenberg S., Zeller T., Wild P.S., Schnabel R.B., Schillert A., Ziegler A., Münzel T.F., White C.C., Rotter J.I., Nalls M., Oudkerk M., Johnson A.D., Newman A.B., Uitterlinden A.G., Massaro J.M., Cunningham J., Harris T.B., Hofman A., Peyser P.A., Borecki I.B., Cupples L.A., Gudnason V., Witteman J.C.
Working group(s)
CARDIoGRAM Consortium
Contributor(s)
Kathiresan S., Reilly MP., Samani NJ., Schunkert H., Assimes TL., Boerwinkle E., Erdmann J., Hall A., Hengstenberg C., Kathiresan S., König IR., Reilly MP., Samani NJ., Thompson JR., Thorsteinsdottir U., Ziegler A., König IR., Thompson JR., Absher D., Chen L., Cupples LA., Halperin E., Li M., Musunuru K., Schillert A., Thorleifsson G., Voight BF., Wells GA., Assimes TL., Deloukas P., Erdmann J., Kathiresan S., König IR., Reilly MP., Roberts R., Samani NJ., Schunkert H., Stewart AF., Absher D., Assimes TL., Fortmann S., Go A., Hlatky M., Iribarren C., Myers R., Quertermous T., Risch N., Blankenberg S., Zeller T., Schillert A., Schnabel R., Lackner K., Tiret L., Cambien F., Rupprecht HJ., Perret C., Münzel T., Bis J., Boerwinkle E., Yii I., Chen D., Adrienne L., Dehghan A., Demissie-Banjaw S., Folsom A., Gudnason V., Harris T., Heckbert S., Levy D., Marciante K., Morrison A., Psaty M., Rice K., Rotter JI., Siscovick DS., Smith N., Taylor KD., van Duijn C., Volcik K., Whitteman J., Ramachandran V., Hofman A., Uitterlinden A., Gretarsdottir S., Gulcher JR., Holm H., Kong A., Stefansson K., Thorgeirsson G., Andersen K., Thorsteinsdottir U., Erdmann J., Fischer M., Grosshennig A., König IR., Lieb W., Linsel P., Wichmann H-., Ziegler A., Schunkert H., Bruse P., Doering A., Hengstenberg C., Illig T., Klopp N., König IR., Linsel P., Loley C., Medack A., Meisinger C., Nahrstedt J., Peters A., Preuss M., Wagner K., Wichmann H-., Willenborg C., Ziegler A., Böhm BO., Dobnig H., Grammer TB., Hoffmann MM., Kleber M., Laaksonen R., Meinitzer A., Winkelmann BR., Pilz S., Scharnagl H., Stojakovic T., Tomaschitz A., Voight BF., Musunuru K., Guiducci C., Burtt N., Gabriel SB., Siscovick DS., O'Donnell CJ., Elosua R., Salomaa V., Schwartz SM., Melander O., Altshuler D., Kathiresan S., Stewart AF., Chen L., Dandona S., Wells GA., Reilly MP., Li M., Qu L., Wilensky R., Matthai W., Hakonarson HH., Devaney J., Susan Burnett M., Pichard AD., Kent KM., Satler L., Lindsay JM., Waksman R., Knouff CW., Waterworth DM., Walker MC., Mooser V., Epstein SE., Rader DJ., Samani NJ., Thompson JR., Braund PS., Nelson CP., Wright BJ., Balmforth AJ., Ball SG., Hall AS.
ISSN
1524-4539 (Electronic)
ISSN-L
0009-7322
Publication state
Published
Issued date
2011
Volume
124
Number
25
Pages
2855-2864
Language
english
Notes
Publication types: Journal Article ; Meta-Analysis
Publication Status: ppublish
Abstract
BACKGROUND: Coronary artery calcification (CAC) detected by computed tomography is a noninvasive measure of coronary atherosclerosis, which underlies most cases of myocardial infarction (MI). We sought to identify common genetic variants associated with CAC and further investigate their associations with MI.
METHODS AND RESULTS: Computed tomography was used to assess quantity of CAC. A meta-analysis of genome-wide association studies for CAC was performed in 9961 men and women from 5 independent community-based cohorts, with replication in 3 additional independent cohorts (n=6032). We examined the top single-nucleotide polymorphisms (SNPs) associated with CAC quantity for association with MI in multiple large genome-wide association studies of MI. Genome-wide significant associations with CAC for SNPs on chromosome 9p21 near CDKN2A and CDKN2B (top SNP: rs1333049; P=7.58×10(-19)) and 6p24 (top SNP: rs9349379, within the PHACTR1 gene; P=2.65×10(-11)) replicated for CAC and for MI. Additionally, there is evidence for concordance of SNP associations with both CAC and MI at a number of other loci, including 3q22 (MRAS gene), 13q34 (COL4A1/COL4A2 genes), and 1p13 (SORT1 gene).
CONCLUSIONS: SNPs in the 9p21 and PHACTR1 gene loci were strongly associated with CAC and MI, and there are suggestive associations with both CAC and MI of SNPs in additional loci. Multiple genetic loci are associated with development of both underlying coronary atherosclerosis and clinical events.
Keywords
Adult, Aged, Aged, 80 and over, Calcinosis/epidemiology, Calcinosis/genetics, Coronary Artery Disease/epidemiology, Coronary Artery Disease/genetics, Female, Follow-Up Studies, Genome-Wide Association Study, Humans, Male, Middle Aged, Myocardial Infarction/epidemiology, Myocardial Infarction/genetics, Polymorphism, Single Nucleotide/genetics, Risk Factors
Pubmed
Web of science
Open Access
Yes
Create date
22/03/2012 10:44
Last modification date
08/05/2019 20:48
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