Vitamin D insufficiency and mild cognitive impairment: cross-sectional association.

Details

Serval ID
serval:BIB_7B1C4F0C2C12
Type
Article: article from journal or magazin.
Collection
Publications
Title
Vitamin D insufficiency and mild cognitive impairment: cross-sectional association.
Journal
European journal of neurology
Author(s)
Annweiler C., Fantino B., Schott A.M., Krolak-Salmon P., Allali G., Beauchet O.
ISSN
1468-1331 (Electronic)
ISSN-L
1351-5101
Publication state
Published
Issued date
07/2012
Peer-reviewed
Oui
Volume
19
Number
7
Pages
1023-1029
Language
english
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Low serum 25-hydroxyvitamin D (25OHD) concentrations have been associated with dementia. The association with mild cognitive impairment (MCI) has not yet been explored. Our aim was to examine the association between vitamin D status and MCI status amongst older community-dwellers with subjective memory complaint.
Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups according to Winblad et al. consensus criteria [i.e., subjects with MCI or cognitively healthy individuals (CHI)]. Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration. The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions. Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders.
Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03). Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002]. Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile).
Low 25OHD concentrations were associated with MCI status in older non-demented community-dwellers with subjective memory complaint.
Keywords
Aged, Aged, 80 and over, Biomarkers/blood, Cognitive Dysfunction/blood, Cognitive Dysfunction/diagnosis, Cognitive Dysfunction/epidemiology, Cross-Sectional Studies, Female, Humans, Male, Vitamin D/blood, Vitamin D Deficiency/blood, Vitamin D Deficiency/diagnosis, Vitamin D Deficiency/epidemiology
Pubmed
Web of science
Create date
11/08/2023 13:49
Last modification date
03/10/2023 5:58
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