Avian malaria and bird humoral immune response.

Details

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State: Public
Version: author
Serval ID
serval:BIB_7B1A0E34DAC9
Type
Article: article from journal or magazin.
Collection
Publications
Title
Avian malaria and bird humoral immune response.
Journal
Malaria journal
Author(s)
Delhaye J., Jenkins T., Glaizot O., Christe P.
ISSN
1475-2875 (Electronic)
ISSN-L
1475-2875
Publication state
Published
Issued date
09/02/2018
Peer-reviewed
Oui
Volume
17
Number
1
Pages
77
Language
english
Notes
Publication types: Journal Article
Publication Status: epublish
Abstract
Plasmodium parasites are known to impose fitness costs on their vertebrate hosts. Some of these costs are due to the activation of the immune response, which may divert resources away from self-maintenance. Plasmodium parasites may also immuno-deplete their hosts. Thus, infected individuals may be less able to mount an immune response to a new pathogen than uninfected ones. However, this has been poorly investigated.
The effect of Plasmodium infection on bird humoral immune response when encountering a novel antigen was tested. A laboratory experiment was conducted on canaries (Serinus canaria) experimentally infected with Plasmodium relictum (lineage SGS1) under controlled conditions. Birds were immune challenged with an intra-pectoral injection of a novel non-pathogenic antigen (keyhole limpet haemocyanin, KLH). One week later they were challenged again. The immune responses to the primary and to the secondary contacts were quantified as anti-KLH antibody production via enzyme-linked immunosorbent assay (ELISA).
There was no significant difference in antibody production between uninfected and Plasmodium infected birds at both primary and secondary contact. However, Plasmodium parasite intensity in the blood increased after the primary contact with the antigen.
There was no effect of Plasmodium infection on the magnitude of the humoral immune response. However, there was a cost of mounting an immune response in infected individuals as parasitaemia increased after the immune challenge, suggesting a trade-off between current control of chronic Plasmodium infection and investment against a new immune challenge.
Keywords
Adjuvants, Immunologic/pharmacology, Animals, Canaries, Female, Hemocyanins/pharmacology, Immunity, Humoral, Malaria, Avian/immunology, Malaria, Avian/parasitology, Male, Plasmodium/physiology, Random Allocation, Keyhole limpet haemocyanin, Plasmodium relictum, Serinus canaria
Pubmed
Web of science
Open Access
Yes
Create date
22/02/2018 16:00
Last modification date
20/08/2019 15:37
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