Severe nose bleeding after intake of acetylsalicylic acid: von Willebrand disease type 2A. Case 9

Details

Serval ID
serval:BIB_7AA8620B5DAF
Type
Article: article from journal or magazin.
Publication sub-type
Case report (case report): feedback on an observation with a short commentary.
Collection
Publications
Institution
Title
Severe nose bleeding after intake of acetylsalicylic acid: von Willebrand disease type 2A. Case 9
Journal
Hamostaseologie
Author(s)
von der Weid  N. X., Mansouri Taleghani  B., Wuillemin  W. A.
ISSN
0720-9355 (Print)
Publication state
Published
Issued date
08/2003
Volume
23
Number
3
Pages
135-7
Notes
Case Reports
Journal Article --- Old month value: Aug
Abstract
This case report of a school boy with a history of severe and repeated episodes of epistaxis presents a short overview of the clinical and laboratory findings which lead to confirm the suspected diagnosis of von Willebrand disease (vWD). Suspicion of defective primary haemostasis should arise when unusual (because of their number or duration) mucosal bleeds appear in an otherwise normal and healthy patient. Because of its definitive inhibitory effect on platelet aggregation, acetylsalicylic acid (more than other non-steroidal anti-inflammatory drugs exerting unselective inhibition of cyclooxygenase) is a strong factor in triggering or sustaining the bleeding disorders in these patients. Among the congenital disorder of primary haemostasis, vWD is by far the most frequent one. The difficulties of laboratory diagnosis of vWD are stressed; the promises and pitfalls of new in vitro methods for measuring primary haemostasis (PFA-100 analyzer) are discussed. An accurate diagnosis of the specific type of vWD is of critical importance for correct patient management as well as for genetic counseling.
Keywords
Anti-Inflammatory Agents, Non-Steroidal/adverse effects Aspirin/*adverse effects Child Diagnosis, Differential Epistaxis/*chemically induced Fibrinolytic Agents/adverse effects Humans Male von Willebrand Disease/diagnosis/*drug therapy
Pubmed
Create date
25/01/2008 10:35
Last modification date
20/08/2019 14:36
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