Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.

Details

Serval ID
serval:BIB_7A8B77785129
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Angiotensin II receptor blockade in normotensive subjects: A direct comparison of three AT1 receptor antagonists.
Journal
Hypertension
Author(s)
Mazzolai L., Maillard M., Rossat J., Nussberger J., Brunner H.R., Burnier M.
ISSN
0194-911X
Publication state
Published
Issued date
1999
Peer-reviewed
Oui
Volume
33
Number
3
Pages
850-5
Language
english
Notes
Publication types: Clinical Trial ; Comparative Study ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't - Publication Status: ppublish
Abstract
Use of angiotensin (Ang) II AT1 receptor antagonists for treatment of hypertension is rapidly increasing, yet direct comparisons of the relative efficacy of antagonists to block the renin-angiotensin system in humans are lacking. In this study, the Ang II receptor blockade induced by the recommended starting dose of 3 antagonists was evaluated in normotensive subjects in a double-blind, placebo-controlled, randomized, 4-way crossover study. At 1-week intervals, 12 subjects received a single dose of losartan (50 mg), valsartan (80 mg), irbesartan (150 mg), or placebo. Blockade of the renin-angiotensin system was assessed before and 4, 24, and 30 hours after drug intake by 3 independent methods: inhibition of the blood pressure response to exogenous Ang II, in vitro Ang II receptor assay, and reactive changes in plasma Ang II levels. At 4 hours, losartan blocked 43% of the Ang II-induced systolic blood pressure increase; valsartan, 51%; and irbesartan, 88% (P<0.01 between drugs). The effect of each drug declined with time. At 24 hours, a residual effect was found with all 3 drugs, but at 30 hours, only irbesartan induced a marked, significant blockade versus placebo. Similar results were obtained when Ang II receptor blockade was assessed with an in vitro receptor assay and by the reactive rise in plasma Ang II levels. This study thus demonstrates that the first administration of the recommended starting dose of irbesartan induces a greater and longer lasting Ang II receptor blockade than that of valsartan and losartan in normotensive subjects.
Keywords
Adult, Angiotensin II, Antihypertensive Agents, Biphenyl Compounds, Blood Pressure, Cross-Over Studies, Double-Blind Method, Humans, Losartan, Male, Receptor, Angiotensin, Type 1, Receptor, Angiotensin, Type 2, Receptors, Angiotensin, Tetrazoles, Time Factors, Valine
Pubmed
Web of science
Create date
05/03/2008 17:40
Last modification date
20/08/2019 15:36
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